Advanced Molecular Surveillance of Hepatitis C Virus

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dc.contributor.authorGoncalves Rossi, Livia Maria [UNESP]
dc.contributor.authorEscobar-Gutierrez, Alejandro
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto de Diagnostico y Referencia Epidemiologicos
dc.date.accessioned2015-10-21T13:13:38Z
dc.date.available2015-10-21T13:13:38Z
dc.date.issued2015-03-01
dc.description.abstractHepatitis C virus (HCV) infection is an important public health problem worldwide. HCV exploits complex molecular mechanisms, which result in a high degree of intrahost genetic heterogeneity. This high degree of variability represents a challenge for the accurate establishment of genetic relatedness between cases and complicates the identification of sources of infection. Tracking HCV infections is crucial for the elucidation of routes of transmission in a variety of settings. Therefore, implementation of HCV advanced molecular surveillance (AMS) is essential for disease control. Accounting for virulence is also important for HCV AMS and both viral and host factors contribute to the disease outcome. Therefore, HCV AMS requires the incorporation of host factors as an integral component of the algorithms used to monitor disease occurrence. Importantly, implementation of comprehensive global databases and data mining are also needed for the proper study of the mechanisms responsible for HCV transmission. Here, we review molecular aspects associated with HCV transmission, as well as the most recent technological advances used for virus and host characterization. Additionally, the cornerstone discoveries that have defined the pathway for viral characterization are presented and the importance of implementing advanced HCV molecular surveillance is highlighted.en
dc.description.affiliationSao Paulo State University (UNESP) - Department of Biology, Institute of Bioscience, Language and Exact Science, Sao Jose do Rio Preto, SP 15054-000, Brazil
dc.description.affiliationInstituto de Diagnostico y Referencia Epidemiologicos, Mexico City 01480, Mexico
dc.description.affiliationUnespSao Paulo State University (UNESP) - Department of Biology, Institute of Bioscience, Language and Exact Science, Sao Jose do Rio Preto, SP 15054-000, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 33004153079P9
dc.format.extent1153-1188
dc.identifierhttp://www.mdpi.com/1999-4915/7/3/1153
dc.identifier.citationViruses-basel. Basel: Mdpi Ag, v. 7, n. 3, p. 1153-1188, 2015.
dc.identifier.doi10.3390/v7031153
dc.identifier.fileWOS000351943000015.pdf
dc.identifier.issn1999-4915
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.urihttp://hdl.handle.net/11449/128793
dc.identifier.wosWOS:000351943000015
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofViruses-basel
dc.relation.ispartofjcr3.761
dc.relation.ispartofsjr1,805
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHepatitis C virusen
dc.subjectAdvanced molecular surveillanceen
dc.subjectMolecular epidemiologyen
dc.subjectMolecular characterizationen
dc.subjectHost factorsen
dc.titleAdvanced Molecular Surveillance of Hepatitis C Virusen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.lattes7991082362671212[3]
unesp.author.orcid0000-0001-5693-6148[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE