Moxonidine reduces pilocarpine-induced salivation in rats

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dc.contributor.authorMoreira, T. S.
dc.contributor.authorTakakura, ACT
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:45Z
dc.date.available2014-05-20T13:45:45Z
dc.date.issued2001-08-13
dc.description.abstractCholinergic, agonists activate salivation and the alpha (2)-adrenergic and imidazoline receptor agonists induce opposite effects. In the present study, we investigated the effects of intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection of moxonidine (an a-adrenergic and imidazoline receptor agonist) on the salivation induced by the cholinergic agonist pilocarpine. Male Holtzman rats wish stainless steel cannula implanted into the lateral ventricle (LV) were used. In rats anesthetized with tribromoethanol (200 mg kg(-1)), saliva was collected using pre-weighed small cotton balls inserted in the animal's mouth. The treatment with moxonidine (5, 10 and 20 nmol in 1 mul) injected,i.c.v. reduced the salivation induced by pilocarpine (1 mg kg(-1)) injected i.p. (48 +/- 5, 17 +/- 2 and 15 +/- 2 mg min(-1) vs. control, 73 +/- 7 mg min(-1)). The same doses of moxonidine injected i.c.v. also reduced the salivary secretion induced by pilocarpine (500 nmol in 1 mul). injected i.c.v. (44 +/- 1, 14 +/- 2 and 20 +/- 3 mg min(-1) vs. control, 51 +/- 2 mg min(-1)). Injection of moxonidine (20 nmol in 0.1 ml) i.p. produced no chance on i.p. pilocarpine-induced salivation (58 +/- 4 mg min(-1) vs. control, 50 +/- 4 mg min(-1)). The results show that central, but not peripheral, injection of moxonidine inhibit,. pilocarpine-induced salivation, suggesting that central mechanisms activated by alpha (2)-adrenergic/imidazoline agonists inhibit cholinergic-induced salivation in rats. (C) 2001 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationPaulista State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespPaulista State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.format.extent32-36
dc.identifierhttp://dx.doi.org/10.1016/S1566-0702(01)00296-X
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 91, n. 1-2, p. 32-36, 2001.
dc.identifier.doi10.1016/S1566-0702(01)00296-X
dc.identifier.issn1566-0702
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16120
dc.identifier.wosWOS:000170516500005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofjcr2.605
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadrenergic and imidazoline receptorspt
dc.subjectsalivary secretionpt
dc.subjectparasympatheticpt
dc.subjectmoxonidinept
dc.titleMoxonidine reduces pilocarpine-induced salivation in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[5]
unesp.author.orcid0000-0001-8270-2652[3]
unesp.author.orcid0000-0002-9789-8296[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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