Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9

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dc.contributor.authorJorge Neto, Salim Demétrio
dc.contributor.authorMachado, Jackeline Souza Rangel
dc.contributor.authorAraujo Júnior, Edward
dc.contributor.authorPalei, Ana Carolina Taveiros
dc.contributor.authorAmaral, Lorena Machado
dc.contributor.authorTanus-Santos, José Eduardo
dc.contributor.authorMarcolin, Alessandra Cristina
dc.contributor.authorDuarte, Geraldo
dc.contributor.authorSandrim, Valéria Cristina [UNESP]
dc.contributor.authorCavalli, Ricardo Carvalho
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Mississipi Medical Center
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:52Z
dc.date.available2018-12-11T17:01:52Z
dc.date.issued2016-12-16
dc.description.abstractObjective: To assess the behavior as well as the comparison between maternal circulating level of biochemical markers (matrix metalloproteinases - MMP-9 and MMP-2) and maternal-fetal Doppler parameters in all three trimesters of pregnancy. Methods: We performed a prospective longitudinal study with 33 healthy pregnant women in three periods of pregnancy: A1 (12w0–14w6d), A2 (22w0d–24w6d) and A3 (34w0d and 36w6d). The following maternal Doppler parameters were assessed: mean pulsatility index (PI) uterine artery, resistance index (RI) umbilical artery and RI middle cerebral artery. The maternal plasma concentrations of MMP-2 and MMP-9 were determined by enzyme immunoassay (ELISA). To compare two (A2 and A3) and three assessments (A1, A2 and A3), we used the paired Student t test and linear regression, respectively. To compare the biomechanical markers and maternal-fetal Doppler parameter, we used the Spearman correlation coefficient (ρ). Results: We observed a significant decrease of PI uterine artery Doppler over the three trimesters of pregnancy (p < 0.01) and RI umbilical artery Doppler overt second to three trimester of pregnancy (p < 0.05). We did not observe significant difference in the maternal plasma level of MMP-2 and MMP-9 between the three trimesters. We did not also observe significant correlation between biochemical markers and maternal-fetal Doppler parameters. Conclusion: Maternal circulating level of MMPs did not modify throughout pregnancy and it did not show correlation with maternal-fetal Doppler parameters.en
dc.description.affiliationDepartment of Obstetrics and Gynecology Ribeirão Preto Medical School University of Sao Paulo (FMRP-USP)
dc.description.affiliationDepartment of Obstetrics Paulista School of Medicine–Federal University of São Paulo (EPM-UNIFESP)
dc.description.affiliationDepartament of Physiology and Biophysics University of Mississipi Medical Center
dc.description.affiliationDepartament of Pharmacology Ribeirão Preto Medical School University of Sao Paulo (FMRP-USP)
dc.description.affiliationDepartament of Pharmacology Botucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationUnespDepartament of Pharmacology Botucatu Medical School São Paulo State University (UNESP)
dc.format.extent3967-3970
dc.identifierhttp://dx.doi.org/10.3109/14767058.2016.1152247
dc.identifier.citationJournal of Maternal-Fetal and Neonatal Medicine, v. 29, n. 24, p. 3967-3970, 2016.
dc.identifier.doi10.3109/14767058.2016.1152247
dc.identifier.issn1476-4954
dc.identifier.issn1476-7058
dc.identifier.scopus2-s2.0-84961207949
dc.identifier.urihttp://hdl.handle.net/11449/172712
dc.language.isoeng
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicine
dc.relation.ispartofsjr0,714
dc.relation.ispartofsjr0,714
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiochemical markers
dc.subjectDoppler
dc.subjectmatrix metalloproteinases
dc.subjectpregnancy
dc.titleLongitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9en
dc.typeArtigo

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