Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats

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dc.contributor.authorSantos, Bruna M.
dc.contributor.authorSantos, Wanderson S.
dc.contributor.authorSolon, Isabelly G.
dc.contributor.authorGarcia, Felipe S.
dc.contributor.authorEmilio-Silva, Maycon T. [UNESP]
dc.contributor.authorJesus, Aline A.
dc.contributor.authorHiruma-Lima, Clélia A. [UNESP]
dc.contributor.authorNascimento, Glauce C.
dc.contributor.authorCárnio, Evelin C.
dc.contributor.authorBranco, Luiz G.S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T14:02:02Z
dc.date.available2023-07-29T14:02:02Z
dc.date.issued2023-08-01
dc.description.abstractOrofacial pain has significant psychological and physiological effects. Citral (3,7-dimethyl-2,6-octadienal) is the main component of Cymbopogon citratus (DC) Stapf, an herb with analgesic properties. Although citral has been considered a potent analgesic, its putative effects on orofacial pain are still unknown. Objective: The objective of this study is to test the hypothesis that citral modulates orofacial pain using two experimental models: formalin-induced hyperalgesia in the vibrissae area and during persistent temporomandibular hypernociception using Complete Freund's Adjuvant - CFA test. Methods: For the formalin test, citral (100 and 300 mg/kg, oral gavage) or its vehicle (Tween 80, 1 %) were given 1 h before the formalin injection subcutaneously (sc) into the vibrissae area. For the CFA model, we analyzed the prophylactic (100 mg/kg of citral by oral gavage, 1 h before CFA injection) and the chronic therapeutic (citral treatment 1-hour post-CFA injection and daily post-CFA injection) effect of citral or its vehicle in animals treated with CFA for 8 days. Results: Citral caused a decrease in formalin-induced local inflammation and the time spent performing nociceptive behavior in a dose-dependent fashion. Similarly, prophylactic and therapeutic citral treatment decreased the CFA-induced persistent mechanical hypernociception in the temporomandibular area. Conclusion: Our data strengthen the notion that citral plays a powerful antinociceptive role by decreasing orofacial hypernociception in formalin and CFA models.en
dc.description.affiliationDepartment of Basic and Oral Biology Dental School of Ribeirão Preto University of São Paulo, Avenida Do Café s/n, São Paulo, SP
dc.description.affiliationDepartment of General and Specialized Nursing Ribeirão Preto College of Nursing - University of São Paulo, SP
dc.description.affiliationDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, SP
dc.description.affiliationUnespDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #16/09364-3
dc.description.sponsorshipIdFAPESP: #16/17681-9
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2023.105734
dc.identifier.citationArchives of Oral Biology, v. 152.
dc.identifier.doi10.1016/j.archoralbio.2023.105734
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.scopus2-s2.0-85159914067
dc.identifier.urihttp://hdl.handle.net/11449/249085
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.sourceScopus
dc.subjectComplete Freund's Adjuvant
dc.subjectFormalin
dc.subjectInflammation
dc.subjectOrofacial pain
dc.subjectTemporomandibular disorders
dc.subjectTrigeminal system
dc.titleOrofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in ratsen
dc.typeArtigo

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