Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli

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dc.contributor.authorSaad, W. A. [UNESP]
dc.contributor.authorLuiz, A. C. [UNESP]
dc.contributor.authorCamargo, L. A.A. [UNESP]
dc.contributor.authorMenani, J. V. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorSilveira, J. E.N. [UNESP]
dc.contributor.authorPaulino, M. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:02Z
dc.date.available2022-04-28T19:54:02Z
dc.date.issued1994-12-01
dc.description.abstractWe investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 μg/μl) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 μg/kg) from 8.49 ± 0.69 to 2.96 ± 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 ± 2.20 to 1.6 ± 0.34 ml/2 h or water deprivation for 24 h from 12.61 ± 0.83 to 5.10 ± 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested.en
dc.description.affiliationDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SP
dc.description.affiliationUnespDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SP
dc.format.extent2909-2913
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 27, n. 12, p. 2909-2913, 1994.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0028576495
dc.identifier.urihttp://hdl.handle.net/11449/223986
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectangiotensin
dc.subjectcentral nervous system
dc.subjectramipril
dc.subjectwater intake
dc.titleInjection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimulien
dc.typeArtigo

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