Macromolecular properties of cepacian in water and in dimethylsulfoxide

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dc.contributor.authorHerasimenka, Yury
dc.contributor.authorCescuttia, Paola
dc.contributor.authorNoguera, Carlos E. Sampaio [UNESP]
dc.contributor.authorRuggiero, José Roberto [UNESP]
dc.contributor.authorUrbani, Ranieri
dc.contributor.authorImpallomeni, Giuseppe
dc.contributor.authorZanetti, Flavio
dc.contributor.authorCampidelli, Stphane
dc.contributor.authorPrato, Maurizio
dc.contributor.authorRizzo, Roberto
dc.contributor.institutionUniv Trieste
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCNR
dc.contributor.institutionEurand SpA
dc.date.accessioned2014-05-20T14:02:48Z
dc.date.available2014-05-20T14:02:48Z
dc.date.issued2008-01-14
dc.description.abstractCepacian is the exopolysaccharide produced by the majority of the so far investigated clinical strains of the Burkholderia cepacia complex. This is a group of nine closely related bacterial species that might cause serious lung infections in cystic fibrosis patients, in some cases leading to death. In this paper the aggregation ability and the conformational properties of cepacian chain were investigated to understand its role in biofilm formation. Viscosity and atomic force microscopy studies in water and in mixed (dimethylsulfoxide/water) solvent indicated the formation of double stranded molecular structures in aqueous solutions. Inter-residue short distances along cepacian chain were investigated by NOE NMR, which showed that two side chains of cepacian were not conformation ally free due to strong interactions with the polymer backbone. These interactions were attributed to hydrogen bonding and contributed to structure rigidity. (c) 2007 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Trieste, Dept Biochem Biophys & Macromol Chem, I-34127 Trieste, Italy
dc.description.affiliationUniv São Paulo, Dept Phys, IBILCE, Sao Jose do Rio Preto, Brazil
dc.description.affiliationCNR, Inst Chem & Technol Polymers, I-95125 Catania, Italy
dc.description.affiliationEurand SpA, I-34012 Trieste, Italy
dc.description.affiliationUniv Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy
dc.description.affiliationUnespUniv São Paulo, Dept Phys, IBILCE, Sao Jose do Rio Preto, Brazil
dc.format.extent81-89
dc.identifierhttp://dx.doi.org/10.1016/j.carres.2007.10.003
dc.identifier.citationCarbohydrate Research. Oxford: Elsevier B.V., v. 343, n. 1, p. 81-89, 2008.
dc.identifier.doi10.1016/j.carres.2007.10.003
dc.identifier.issn0008-6215
dc.identifier.urihttp://hdl.handle.net/11449/22123
dc.identifier.wosWOS:000253029300009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Research
dc.relation.ispartofjcr2.074
dc.relation.ispartofsjr0,617
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectExopolysaccharideen
dc.subjectBurkholderia cepacia complexen
dc.subjectbiofilmen
dc.subjectconformational propertiesen
dc.subjectdimethylsulfoxide solutionsen
dc.titleMacromolecular properties of cepacian in water and in dimethylsulfoxideen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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