Longitudinal Study of Plasma Visfatin/Nicotinamide Phosphoribosyltransferase (NAMPT) Levels in Healthy Pregnant Women

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dc.contributor.authorNunes, Priscila R. [UNESP]
dc.contributor.authorCavalli, Ricardo C.
dc.contributor.authorBelo, Vanessa A.
dc.contributor.authorSandrim, Valeria C. [UNESP]
dc.contributor.authorLuizon, Marcelo R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFederal University of Ouro Preto (UFOP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2023-07-29T13:52:44Z
dc.date.available2023-07-29T13:52:44Z
dc.date.issued2023-01-01
dc.description.abstractVisfatin/nicotinamide phosphorybosil transferase (NAMPT) is a novel adipocytokine with potential roles in the pathophysiology of metabolic disorders, including gestational disorders. However, there is no clear interpretation regarding the circulating visfatin levels in a healthy pregnancy. Therefore, we conducted the first longitudinal study of plasma visfatin levels that followed up healthy pregnant women until the third trimester, including the postpartum period (PPP). The study recruited healthy women with singleton pregnancy who were not using any drug (including tobacco and alcohol). We have excluded pregnant women who did not attend all scheduled exams and developed gestational diabetes or hypertension, obesity, preeclampsia, or any infections during pregnancy. Nine women were considered eligible and examined during all three trimesters of pregnancy and between 8 and 12 weeks postpartum (PPP). Visfatin/NAMPT concentrations were measured in EDTA-plasma by ELISA. The mean age of pregnant women included was 22±5 years (54% primiparous), and the mean of gestational age at delivery was 40±1.2 weeks. Mean systolic and diastolic blood pressures were 90 and 70 mmHg, respectively. Mean values (± standard error mean) of visfatin concentrations (μg/L) during trimesters were 11.38±1.45 (first, 11–14 weeks), 9.18±1.82 (second, 20–24 weeks), 18.67±2.65 (third, 34–36 weeks), and 10.12±1.49 in the PPP. The value of the third trimester was significantly higher than the second trimester, and significantly reduced in the PPP (p<0.05, ANOVA with Bonferroni’s multiple comparison tests). Visfatin/NAMPT levels are significantly lower in the PPP, suggesting that factors stimulating its production would be limited to pregnancy, thereby contributing to its potential application as a biomarker in pregnancy complications.en
dc.description.affiliationDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, Botucatu
dc.description.affiliationDepartment of Gynecology and Obstetrics Ribeirao Preto Medical School University of Sao Paulo (USP), Ribeirao Preto
dc.description.affiliationDepartment of Pharmacy School of Pharmacy Federal University of Ouro Preto (UFOP), Minas Gerais
dc.description.affiliationDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG), Minas Gerais
dc.description.affiliationUnespDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, Botucatu
dc.identifierhttp://dx.doi.org/10.1007/s43032-023-01246-4
dc.identifier.citationReproductive Sciences.
dc.identifier.doi10.1007/s43032-023-01246-4
dc.identifier.issn1933-7205
dc.identifier.issn1933-7191
dc.identifier.scopus2-s2.0-85153939302
dc.identifier.urihttp://hdl.handle.net/11449/248752
dc.language.isoeng
dc.relation.ispartofReproductive Sciences
dc.sourceScopus
dc.subjectAdipocytokines
dc.subjectCytokines
dc.subjectextracellular NAMPT (eNAMPT)
dc.subjectNicotinamide phosphoribosyltransferase (NAMPT)
dc.subjectPregnancy
dc.subjectVisfatin
dc.titleLongitudinal Study of Plasma Visfatin/Nicotinamide Phosphoribosyltransferase (NAMPT) Levels in Healthy Pregnant Womenen
dc.typeArtigo
unesp.author.orcid0000-0002-8041-5753[1]
unesp.author.orcid0000-0001-5010-4914[2]
unesp.author.orcid0000-0002-6648-8518[3]
unesp.author.orcid0000-0002-6168-7470[4]
unesp.author.orcid0000-0002-8331-3525[5]

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