TRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breathe

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dc.contributor.authorPatrone, Luis Gustavo A. [UNESP]
dc.contributor.authorDuarte, Jaime B. [UNESP]
dc.contributor.authorBícego, Kênia Cardoso [UNESP]
dc.contributor.authorSteiner, Alexandre A.
dc.contributor.authorRomanovsky, Andrej A.
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSt. Joseph’s Hospital and Medical Center
dc.date.accessioned2019-10-06T16:19:23Z
dc.date.available2019-10-06T16:19:23Z
dc.date.issued2019-01-01
dc.description.abstractReceptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O 2 ) and hypercapnia (7% CO 2 ) by measuring pulmonary ventilation ( ˙V E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 µg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.en
dc.description.affiliationDepartment of Animal Morphology and Physiology Faculty of Agricultural and Veterinarian Sciences UNESP at Jaboticabal, Rod. Prof. Paulo Donato Castellane s/n
dc.description.affiliationDepartment of Immunology Institute of Biomedical Sciences University of Sao Paulo
dc.description.affiliationThermoregulation and Systemic Inflammation Laboratory (FeverLab) Trauma Research St. Joseph’s Hospital and Medical Center
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology Faculty of Agricultural and Veterinarian Sciences UNESP at Jaboticabal, Rod. Prof. Paulo Donato Castellane s/n
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2015/24785-2
dc.description.sponsorshipIdFAPESP: 2016/24577-3
dc.description.sponsorshipIdCAPES: 2017/05318-0
dc.description.sponsorshipIdFAPESP: 2017/05318-0
dc.description.sponsorshipIdCNPq: 310293/2015-4
dc.identifierhttp://dx.doi.org/10.3390/ph12010019
dc.identifier.citationPharmaceuticals, v. 12, n. 1, 2019.
dc.identifier.doi10.3390/ph12010019
dc.identifier.issn1424-8247
dc.identifier.scopus2-s2.0-85062338083
dc.identifier.urihttp://hdl.handle.net/11449/188792
dc.language.isoeng
dc.relation.ispartofPharmaceuticals
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectChannels
dc.subjectChemosensitivity
dc.subjectHypercapnia
dc.subjectHypothermia
dc.subjectVentilation
dc.titleTRPV1 inhibits the ventilatory response to hypoxia in adult rats, but not the CO 2 -drive to breatheen
dc.typeArtigo

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Artigos - Morfologia e Fisiologia Animal - FCAV