Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor

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dc.contributor.authorSantos, Daniela Pereira dos [UNESP]
dc.contributor.authorBergamini, Marcio Fernando
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.date.accessioned2014-05-20T14:19:53Z
dc.date.available2014-05-20T14:19:53Z
dc.date.issued2010-10-01
dc.description.abstractThe poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples.en
dc.description.affiliationUniv São Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUFPR, Ctr Politecn, Setor Ciencias Exatas, Dept Quim, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationUnespUniv São Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 3/06598-3
dc.description.sponsorshipIdFAPESP: 04/00111-8
dc.format.extent1399-1410
dc.identifierhttp://www.electrochemsci.org/papers/vol5/5101399.pdf
dc.identifier.citationInternational Journal of Electrochemical Science. Belgrade: Electrochemical Science Group, v. 5, n. 10, p. 1399-1410, 2010.
dc.identifier.fileWOS000282329800001.pdf
dc.identifier.issn1452-3981
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.urihttp://hdl.handle.net/11449/25980
dc.identifier.wosWOS:000282329800001
dc.language.isoeng
dc.publisherElectrochemical Science Group
dc.relation.ispartofInternational Journal of Electrochemical Science
dc.relation.ispartofjcr1.369
dc.relation.ispartofsjr0,366
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDoxorubicinen
dc.subjectpoly-L-glutamic aciden
dc.subjectadsorptionen
dc.subjectsemiquinone free radicalen
dc.subjecturineen
dc.titleApproach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensoren
dc.typeArtigo
dcterms.rightsHolderElectrochemical Science Group
unesp.author.orcid0000-0002-2296-1393[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Analítica - IQ