Aumento dos níveis de csf de tau total em pacientes com patologia subcutânea cerebrovascular e comprometimento cognitivo

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dc.contributor.authorRadanovic, Márcia
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.authorSilva, Lis Gomes
dc.contributor.authorTalib, Leda L.
dc.contributor.authorForlenza, Orestes V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:23:44Z
dc.date.available2018-12-11T17:23:44Z
dc.date.issued2017-10-01
dc.description.abstractCognitive impairment includes mild cognitive decline and dementia, such as Alzheimer’s disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample of cognitively impaired and unimpaired older adults with concomitant subcortical cerebrovascular burden. Methods: Seventy-eight older adults attending an outpatient psychogeriatric clinic were enrolled. Diagnoses were based on clinical, neuropsychological, laboratory, and neuroimaging data. Participants were classified into: cognitively normal (controls, n=30), mild cognitive impairment (MCI, n=34), and dementia (AD, n=14). All subjects were submitted to CSF analyses for determination of amyloid-beta (Aβ1-42), total tau (t-tau), phosphorylated tau (p-tau) and Aβ1-42/p-tau ratio according to the Luminex method. MRI was performed in all individuals, and was scored independently by two experts according to Fazekas scale. Statistical analyses were conducted with the aid of general linear model procedures, and the Chi-squared test. Results: T-tau levels were significantly associated with subcortical lesion pattern when Fazekas was considered as a group factor. CSF biomarkers were not associated with MCI, AD, or controls when considered separately. There was a tendency for reduction in CSF Aβ1-42 together with increasing Fazekas scores, but without statistical significance. Comparisons of Aβ1-42 and t-tau with each clinical group or with each neuroimaging pattern did not reach statistical differences. Likewise, Fazekas scores had no impact on CAMCOG scores. Conclusion: We found a significant association between t-tau levels and subcortical lesions when all Fazekas classifications were considered as a single group; comparisons of Fazekas subgroups and CSF biomarkers did not reach significance.en
dc.description.affiliationLaboratório de Neurociencias LIM27 Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de São Paulo
dc.description.affiliationBiosciences Institute Universidade Estadual Paulista (UNESP), Campus of Rio Claro
dc.description.affiliationUnespBiosciences Institute Universidade Estadual Paulista (UNESP), Campus of Rio Claro
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 8 09/52825-8
dc.format.extent419-425
dc.identifierhttp://dx.doi.org/10.1590/1980-57642016dn11-040012
dc.identifier.citationDementia e Neuropsychologia, v. 11, n. 4, p. 419-425, 2017.
dc.identifier.doi10.1590/1980-57642016dn11-040012
dc.identifier.fileS1980-57642017000400419.pdf
dc.identifier.issn1980-5764
dc.identifier.scieloS1980-57642017000400419
dc.identifier.scopus2-s2.0-85039701488
dc.identifier.urihttp://hdl.handle.net/11449/177072
dc.language.isoeng
dc.relation.ispartofDementia e Neuropsychologia
dc.relation.ispartofsjr0,205
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAmyloid-β
dc.subjectCerebrospinal fluid biomarkers
dc.subjectSubcortical vascular lesions
dc.subjectTau protein
dc.subjectVascular cognitive impairment
dc.titleAumento dos níveis de csf de tau total em pacientes com patologia subcutânea cerebrovascular e comprometimento cognitivopt
dc.title.alternativeIncreased CSF levels of total tau in patients with subcortical cerebrovascular pathology and cognitive impairmenten
dc.typeArtigo

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