The use of bone scintigraphy to detect active Hansen's disease in mutilated patients

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dc.contributor.authorBraga, FJHN
dc.contributor.authorFoss, N. T.
dc.contributor.authorFerriolli, E.
dc.contributor.authorPagnano, C.
dc.contributor.authorMiranda, JRD
dc.contributor.authorde Moraes, R.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSecretaria Saude
dc.date.accessioned2014-05-20T13:49:19Z
dc.date.available2014-05-20T13:49:19Z
dc.date.issued1999-11-01
dc.description.abstractMutilation of extremities was very frequent in patients affected by leprosy in the past; although it is now much less common, it is still seen, mainly in patients with long-term disease. In general, mutilation of the nose and ears is caused by the bacillus and mutilation of the hands and feet a consequence of chronic trauma. Leprosy must be chronically treated and any decision to interrupt therapy is based on laboratory tests and biopsy. Scintigraphy is a non-invasive procedure which could be of great value in to determining disease activity. We studied eight patients (five males and three females, aged 64-73 years) who presented with mutilation of the nose (2), ear (1), feet (3) or foot and hand (2), Conventional three-phase bone scintigraphy (750 MBq) and X-ray examinations of the affected areas were performed in all patients. Bone scintigraphy was abnormal in four patients (the presence of bacilli was confirmed by biopsy in two of them), and normal in the other four. In all patients except for the one with ear mutilation, radiography only showed the absence of bone. We conclude that bone scintigraphy is very useful to determine disease activity in cases of mutilation caused by leprosy. It seems to be superior to conventional radiography and may enable bone biopsies to be avoided.en
dc.description.affiliationUSP, Fac Med Ribeirao Preto, Hosp Clin, Seccao Med Nucl, São Paulo, Brazil
dc.description.affiliationUNESP, Inst Biociencias, Dept Fis & Biofis, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUSP, Fac Med Ribeirao Preto, Dept Clin Med, São Paulo, Brazil
dc.description.affiliationSecretaria Saude, Ribeirao Preto, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Fis & Biofis, BR-18618000 Botucatu, SP, Brazil
dc.format.extent1497-1499
dc.identifierhttp://dx.doi.org/10.1007/s002590050486
dc.identifier.citationEuropean Journal of Nuclear Medicine. New York: Springer Verlag, v. 26, n. 11, p. 1497-1499, 1999.
dc.identifier.doi10.1007/s002590050486
dc.identifier.issn0340-6997
dc.identifier.urihttp://hdl.handle.net/11449/17564
dc.identifier.wosWOS:000083622100018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Nuclear Medicine
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectleprosypt
dc.subjectHansen's diseasept
dc.subjectscintigraphypt
dc.subjectmutilationpt
dc.subjecttechnetium-99m methylene diphosphonatept
dc.titleThe use of bone scintigraphy to detect active Hansen's disease in mutilated patientsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0002-8306-8056[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Física e Biofísica - IBB