INTRAGASTRIC INFECTION OF CONVENTIONAL AND GERM-FREE MICE WITH GIARDIA-LAMBLIA

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dc.contributor.authorTorres, MRF
dc.contributor.authorSilva, MEC
dc.contributor.authorVieira, E. C.
dc.contributor.authorBambirra, E. A.
dc.contributor.authorSogayar, MIT
dc.contributor.authorPena, F. J.
dc.contributor.authorNICOLI, JR
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:24:53Z
dc.date.available2014-05-20T15:24:53Z
dc.date.issued1992-01-01
dc.description.abstractThe effects of experimental infection with Giardia lamblia were studied in 30-day old conventional and germfree CFW mice (7 animals in each group) of both sexes. Cysts were observed in the feces of both groups 6 to 7 days after intragastric infection of each animal with about 2.5 x 10(5) G. lamblia trophozoites. Fecal cyst level was statistically higher in germfree mice (about 10(5) cysts/g feces) when compared with the conventional group (about 10(4) cysts/g feces). The peak of infection in the conventional group apparently occurred on the 10th day after infection as indicated by an increase of fecal weight and by histopathological examination. Intense infiltration of the lamina propria and high reactional hyperplasia of the lymphoid component were observed in the conventional group. There was no infiltration or hyperplasia in germfree infected mice and fecal weight was relatively constant throughout the experiment. These results suggest that, as is the case for other intestinal pathogenic protozoa, the intestinal microflora is indispensable for the expression of the pathogenicity but not for the multiplication of G. lamblia.en
dc.description.affiliationUNIV FED MINAS GERAIS,INST CIENCIAS BIOL,DEPT BIOQUIM IMMUNOL,GNOTOBIOL LAB,CAIXA POSTAL 2486,BR-30161 BELO HORIZONTE,MG,BRAZIL
dc.description.affiliationUNIV FED MINAS GERAIS,FAC MED,DEPT PEDIAT,BR-30161 BELO HORIZONTE,MG,BRAZIL
dc.description.affiliationUNIV FED MINAS GERAIS,FAC MED,DEPT ANAT PATOL,BR-30161 BELO HORIZONTE,MG,BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOT,DEPT PARASITOL,BR-18600 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOT,DEPT PARASITOL,BR-18600 BOTUCATU,SP,BRAZIL
dc.format.extent349-352
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 25, n. 4, p. 349-352, 1992.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/35413
dc.identifier.wosWOS:A1992HT30200004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGIARDIA-LAMBLIApt
dc.subjectGERM-FREE MICEpt
dc.subjectCONVENTIONAL MICEpt
dc.titleINTRAGASTRIC INFECTION OF CONVENTIONAL AND GERM-FREE MICE WITH GIARDIA-LAMBLIAen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
dcterms.rightsHolderAssociação Bras Divulg Cientifica
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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