Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?

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dc.contributor.authorMonteiro, Rosângela Lucinda Rocha
dc.contributor.authorKobayasi, Maria Aparecida Marchesan Rodrigues [UNESP]
dc.contributor.authorde Araujo, Marina Rachel
dc.contributor.authorMonteiro, Dafny Rocha
dc.contributor.authorAndreollo, Nelson Adami
dc.contributor.institutionUniversidade do Vale do Sapucaí (UNIVÁS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionCentro Universitário de Faculdades de Ensino Associadas (UNIFAE)
dc.date.accessioned2021-06-25T10:34:58Z
dc.date.available2021-06-25T10:34:58Z
dc.date.issued2020-01-01
dc.description.abstractPurpose: To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux. Methods: One hundred and twenty Wistar rats were divided into three groups: Group I (n=40) – gastrotomy; Group II (n=40) – duodenogastric reflux after gastrojejunoanastomosis latero-lateral (DGR); Group III (n=40) – retrograde duodenogastric reflux through the pylorus (DGR-P). The groups were divided into 4 subgroups of 10 animals, respectively treated for 16 weeks with water, omeprazole 1.6 mg / rat / day, nitrite 600 mg / kg / day and omeprazole plus nitrite simultaneously. Results: The proliferative lesions found were: squamous hyperplasia – 69.1%, adenomatous hyperplasia in the anastomosis – 29.1% and prepyloric adenomatous hyperplasia – 42.5%. Adenocarcinomas were registered in 7 animals (5.8%): one in Group I (omeprazole plus nitrite), two in Group II (omeprazole and nitrite plus omeprazole) and four in Group III (water, nitrite, omeprazole and omeprazole plus nitrite). Conclusions: The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats.en
dc.description.affiliationSchool of Medicine Universidade do Vale do Sapucaí (UNIVÁS)
dc.description.affiliationDepartment of Pathology Medical School Universidade Estadual Paulista (UNESP)
dc.description.affiliationExperimental Surgery Laboratory School of Medical Sciences Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliationCentro Universitário de Faculdades de Ensino Associadas (UNIFAE)
dc.description.affiliationDigestive Diseases Surgical Unit and Gastrocentro School of Medical Sciences UNICAMP
dc.description.affiliationUnespDepartment of Pathology Medical School Universidade Estadual Paulista (UNESP)
dc.format.extent1-9
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020200090000004
dc.identifier.citationActa Cirurgica Brasileira, v. 35, n. 9, p. 1-9, 2020.
dc.identifier.doi10.1590/s0102-865020200090000004
dc.identifier.fileS0102-86502020000900202.pdf
dc.identifier.issn1678-2674
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502020000900202
dc.identifier.scopus2-s2.0-85091813212
dc.identifier.urihttp://hdl.handle.net/11449/206596
dc.language.isoeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCarcinogenesis
dc.subjectDuodenogastric Reflux
dc.subjectNitrites
dc.subjectOmeprazole
dc.subjectRats
dc.titleOmeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?en
dc.typeArtigo

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