High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study

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dc.contributor.authorBraz, Mariana G. [UNESP]
dc.contributor.authorCarvalho, Lorena I. M. [UNESP]
dc.contributor.authorChen, Chung-Yen O.
dc.contributor.authorBlumberg, Jeffrey B.
dc.contributor.authorSouza, Kátina M. [UNESP]
dc.contributor.authorArruda, Nayara M. [UNESP]
dc.contributor.authorFilho, Daniel A. A. [UNESP]
dc.contributor.authorResende, Ludimila O. [UNESP]
dc.contributor.authorFaria, Renata T. B. G. [UNESP]
dc.contributor.authorCanário, Clara d'A. [UNESP]
dc.contributor.authorde Carvalho, Lídia R. [UNESP]
dc.contributor.authorCorrêa, Camila R. [UNESP]
dc.contributor.authorBraz, José Reinaldo C. [UNESP]
dc.contributor.authorBraz, Leandro G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts University
dc.date.accessioned2020-12-12T01:55:06Z
dc.date.available2020-12-12T01:55:06Z
dc.date.issued2020-05-01
dc.description.abstractThis cross-sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus-MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL-17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3-fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.en
dc.description.affiliationGENOTOX Laboratory - UNIPEX Department of Anesthesiology Medical School São Paulo State University - UNESP
dc.description.affiliationAntioxidants Research Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University
dc.description.affiliationDepartment of Bioestatistics Institute of Biosciences São Paulo State University - UNESP
dc.description.affiliationDepartment of Pathology Medical School São Paulo State University - UNESP
dc.description.affiliationUnespGENOTOX Laboratory - UNIPEX Department of Anesthesiology Medical School São Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Bioestatistics Institute of Biosciences São Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Pathology Medical School São Paulo State University - UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipAgricultural Research Service
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 14527-13-8
dc.description.sponsorshipIdCNPq: 164242/2014-7
dc.description.sponsorshipIdAgricultural Research Service: 1950-51000-087
dc.description.sponsorshipIdFAPESP: 2013/12120-0
dc.description.sponsorshipIdFAPESP: 2013/18075-7
dc.description.sponsorshipIdFAPESP: 2013/21130-0
dc.description.sponsorshipIdFAPESP: 2014/08661-9
dc.description.sponsorshipIdFAPESP: 2015/06420-7
dc.description.sponsorshipIdCNPq: 472453/2013-0
dc.format.extent512-520
dc.identifierhttp://dx.doi.org/10.1111/ina.12643
dc.identifier.citationIndoor Air, v. 30, n. 3, p. 512-520, 2020.
dc.identifier.doi10.1111/ina.12643
dc.identifier.issn1600-0668
dc.identifier.issn0905-6947
dc.identifier.scopus2-s2.0-85078653857
dc.identifier.urihttp://hdl.handle.net/11449/200006
dc.language.isoeng
dc.relation.ispartofIndoor Air
dc.sourceScopus
dc.subjectgenomic instability
dc.subjectindoor air pollution
dc.subjectinflammation
dc.subjectinhalation anesthetics
dc.subjectoxidative stress
dc.subjectwork environment
dc.titleHigh concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional studyen
dc.typeArtigo
unesp.author.orcid0000-0003-4413-226X[1]

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Artigos - Bioestatística - IBB
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