Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery

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dc.contributor.authorPrezotti, Fabíola Garavello [UNESP]
dc.contributor.authorSiedle, Izabel
dc.contributor.authorBoni, Fernanda Isadora [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorMüller, Ingrid
dc.contributor.authorCury, Beatriz Stringhetti Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Albstadt-Sigmaringen
dc.date.accessioned2020-12-12T01:46:19Z
dc.date.available2020-12-12T01:46:19Z
dc.date.issued2020-02-07
dc.description.abstractFilms of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.en
dc.description.affiliationDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP
dc.description.affiliationFaculty for Pharmaceutical Engineering University of Albstadt-Sigmaringen
dc.description.affiliationUnespDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP
dc.format.extent159-167
dc.identifierhttp://dx.doi.org/10.1080/10837450.2019.1682608
dc.identifier.citationPharmaceutical Development and Technology, v. 25, n. 2, p. 159-167, 2020.
dc.identifier.doi10.1080/10837450.2019.1682608
dc.identifier.issn1097-9867
dc.identifier.issn1083-7450
dc.identifier.scopus2-s2.0-85075229584
dc.identifier.urihttp://hdl.handle.net/11449/199676
dc.language.isoeng
dc.relation.ispartofPharmaceutical Development and Technology
dc.sourceScopus
dc.subjectcontrolled release
dc.subjectmechanical properties
dc.subjectmucoadhesion
dc.subjectSolvent casting method
dc.subjectswelling ability
dc.subjectwater vapor permeability
dc.titleMucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug deliveryen
dc.typeArtigo

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