Níveis de sedação determinados pela clonidina e midazolam na medicação pré-anestésica. Avaliação clínica e eletroencefalográfica bispectral

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dc.contributor.authorBraz, Leandro Gobbo [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorDe Mello, Maria Zoé Turchiari [UNESP]
dc.contributor.authorDe Carvalho, Lidia Raquel [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:59:31Z
dc.date.available2022-04-28T19:59:31Z
dc.date.issued2002-02-05
dc.description.abstractBackground and Objectives - This study aimed at evaluating clonidine - an α2-agonist - and midazolam - a benzodiazepine - sedative effects in preanesthetic medication by clinical and electroencephalographic analysis. Methods - After institutional approval and their informed written consent, participated in this study 45 patients aged 18 to 65 years, physical status ASA I, who were randomly distributed in placebo (P), clonidine (C) or midazolam (M) groups. Patients were premedicated with oral placebo, 150 μg clonidine or 15 mg midazolam 60 minutes before anesthetic induction (n = 15 per group). Monitoring consisted of electrocardiogram (DII), non-invasive blood pressure, heart rate, oxygen saturation, respiratory rate, axillary and operating room temperature and bispectral electroencephalography to determine bispectral index (BIS). These attributes and sedation scale (1-anxious, 2-calm, 3-sleepy, 4-sleeping with reflex, 5-sleeping without reflex) were obtained at 0 (M0), 15 (M15), 30 (M30), 40 (M40), 50 (M50) and 60 (M60) minutes after medication. Results - There were no significant differences in respiratory, hemodynamic and temperature parameters. There has been a significant difference among groups in sedation scale (M60: M=C>P) and BIS (M50 and M60: M=C>P). Conclusions - In our conditions, clonidine and midazolam have determined similar sedation levels in patients ASA I when evaluated by sedation scale and BIS. No hemodynamic and respiratory changes were observed with both drugs.en
dc.description.affiliationDept. de Anestesiologia da FMB UNESP, Distrito de Rubião Junior, 18618-970 Botucatu, SP
dc.description.affiliationUnespDept. de Anestesiologia da FMB UNESP, Distrito de Rubião Junior, 18618-970 Botucatu, SP
dc.format.extent9-18
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 52, n. 1, p. 9-18, 2002.
dc.identifier.issn0034-7094
dc.identifier.scopus2-s2.0-18144446847
dc.identifier.urihttp://hdl.handle.net/11449/224526
dc.language.isopor
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.sourceScopus
dc.subjectClonidine, midazolam
dc.subjectDepth of anesthesia, bispectral index
dc.subjectLevel
dc.subjectMonitoring
dc.subjectPreanesthetic Medication
dc.subjectSedation
dc.titleNíveis de sedação determinados pela clonidina e midazolam na medicação pré-anestésica. Avaliação clínica e eletroencefalográfica bispectralpt
dc.title.alternativeSedation levels of oral preanesthetic clonidine and midazolam. Clinical and electroencephalographic bispectral analysisen
dc.typeArtigo

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Artigos - Anestesiologia - FMB