Suppression of TNF- induced NFB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention

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dc.contributor.authorMorais, Mauro C. C. [UNESP]
dc.contributor.authorLuqman, Suaib
dc.contributor.authorKondratyuk, Tamara P.
dc.contributor.authorPetronio, Maicon S. [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorSoares, Christiane P.
dc.contributor.authorPezzuto, John M.
dc.contributor.institutionUniv Hawaii
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCSIR
dc.date.accessioned2014-05-20T14:21:14Z
dc.date.available2014-05-20T14:21:14Z
dc.date.issued2010-01-01
dc.description.abstractGallic acid (3,4,5-trihydroxybenzoic acid), found in many plants either in free-form or part of tannins, is known to possess anti-microbial, antioxidant and cytotoxic properties. NFB regulates the expression of several genes involved in carcinogenesis. These include anti-apoptotic, cytokines and cell cycle-regulatory genes. It is well established that the transcriptional factor NFB is deregulated in many forms of cancer. Thus, agents that can suppress NFB activation have the potential of suppressing carcinogenesis. In the present investigation, gallic acid was isolated from Alchornea glandulosa (Euphorbiaceae) and eight esters were synthesised. These compounds were evaluated against TNF--induced NFB activation with stably transfected 293/NFB-Luc human embryonic kidney cells. Gallates with IC50 values in a range of 10-56 mu M mediated inhibitory activity higher than gallic acid (IC50 76.0 +/- 4.9 mu M). In addition to inhibiting NFB activation, gallic acid mediated a modest cytotoxic effect, and some of the gallates affected cell viability at the tested concentrations. Based on these results, suppression of NFB activation by gallate esters could play a chemopreventive role in carcinogenesis.en
dc.description.affiliationUniv Hawaii, Coll Pharm, Hilo, HI 96720 USA
dc.description.affiliationSão Paulo State Univ UNESP, Dept Clin Anal, Cytol & Cellular Biol Lab, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationCSIR, Genet Resources & Biotechnol Div, Cent Inst Med & Aromat Plants, IUSSTF, Lucknow 226015, Uttar Pradesh, India
dc.description.affiliationSão Paulo State Univ UNESP, Dept Organ Chem, NuBBE Nucleus Bioassays Biosynth & Ecophysiol Nat, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Clin Anal, Cytol & Cellular Biol Lab, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Organ Chem, NuBBE Nucleus Bioassays Biosynth & Ecophysiol Nat, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipNational Cancer Institute
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIndo-US Science and Technology Forum (IUSSTF), New Delhi
dc.description.sponsorshipIdNational Cancer Institute: P01 CA48112
dc.description.sponsorshipIdFAPESP: 04/07932-7
dc.format.extent1758-1765
dc.identifierhttp://dx.doi.org/10.1080/14786410903335232
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 24, n. 18, p. 1758-1765, 2010.
dc.identifier.doi10.1080/14786410903335232
dc.identifier.issn1478-6419
dc.identifier.lattes4702004904231248
dc.identifier.lattes4484083685251673
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/26353
dc.identifier.wosWOS:000283687900012
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.ispartofjcr1.928
dc.relation.ispartofsjr0,671
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgallic aciden
dc.subjectNFB pathwayen
dc.subjectcytotoxicityen
dc.subject293en
dc.subjectNFB cellsen
dc.subjectAlchornea glandulosaen
dc.subjectcancer chemopreventionen
dc.titleSuppression of TNF- induced NFB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemopreventionen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.lattes4702004904231248[6]
unesp.author.lattes4484083685251673
unesp.author.lattes1768025290373669[8]
unesp.author.orcid0000-0002-1516-7765[6]
unesp.author.orcid0000-0003-1740-7360[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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