Efficacy and safety of glucose, glucose and polidocanol combination, liquid polidocanol and polidocanol foam in the treatment of reticular veins: A randomized study in rabbits

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dc.contributor.authorLucio Filho, Carlos Eduardo Pinheiro [UNESP]
dc.contributor.authorBertanha, Matheus [UNESP]
dc.contributor.authorPrata, Marcela Polachini [UNESP]
dc.contributor.authorCarvalho, Lídia Raquel de [UNESP]
dc.contributor.authorJaldin, Rodrigo Gibin [UNESP]
dc.contributor.authorSobreira, Marcone Lima [UNESP]
dc.contributor.authorJanzen, Jan [UNESP]
dc.contributor.authorYoshida, Winston Bonetti [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHistopathologie und VascPath
dc.date.accessioned2021-06-25T10:35:29Z
dc.date.available2021-06-25T10:35:29Z
dc.date.issued2021-05-01
dc.description.abstractObjective: To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears. Methods: Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol-glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy (luminal occlusion), complications (phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology (sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis). Results: Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis (p = 0.003), 46.15% ulceration (p = 0.003), and 69.2% local inflammation (p < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis (p = 0.03) in the foam group. Conclusions: Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events.en
dc.description.affiliationDepartment of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP
dc.description.affiliationDepartment of Biostatistics-Biosciences Institute Paulista State University UNESP
dc.description.affiliationHistopathologie und VascPath
dc.description.affiliationUnespDepartment of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP
dc.description.affiliationUnespDepartment of Biostatistics-Biosciences Institute Paulista State University UNESP
dc.format.extent303-312
dc.identifierhttp://dx.doi.org/10.1177/0268355520964293
dc.identifier.citationPhlebology, v. 36, n. 4, p. 303-312, 2021.
dc.identifier.doi10.1177/0268355520964293
dc.identifier.issn1433-3031
dc.identifier.issn0268-3555
dc.identifier.scopus2-s2.0-85092290608
dc.identifier.urihttp://hdl.handle.net/11449/206630
dc.language.isoeng
dc.relation.ispartofPhlebology
dc.sourceScopus
dc.subjectanimal models
dc.subjectefficacy
dc.subjectsafety
dc.subjectsclerosing solutions
dc.subjectsclerotherapy
dc.subjectVaricose veins
dc.titleEfficacy and safety of glucose, glucose and polidocanol combination, liquid polidocanol and polidocanol foam in the treatment of reticular veins: A randomized study in rabbitsen
dc.typeArtigo
unesp.author.orcid0000-0002-9960-0115[1]
unesp.author.orcid0000-0002-6851-2841[2]
unesp.author.orcid0000-0003-2271-5878[6]

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