Immunohistochemical detection of metalloproteinase-9 (MMP-9), anti-oxidant like 1 protein (AOP-1) and synaptosomal-associated protein (SNAP-25) in the cerebella of dogs naturally infected with spontaneous canine distemper

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dc.contributor.authorBregano, Livia Castanhas [UNESP]
dc.contributor.authorAgostinho, Sabrina Donatoni [UNESP]
dc.contributor.authorRocatti, F. T. L. B. [UNESP]
dc.contributor.authorPires, Marcilia Cristina
dc.contributor.authorRiva, Henrique Guimarães [UNESP]
dc.contributor.authorLuvizotto, Maria Cecília Rui [UNESP]
dc.contributor.authorCardoso, Tereza Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:53:44Z
dc.date.available2016-01-28T16:53:44Z
dc.date.issued2011
dc.description.abstractIn most viral infections of the central nervous system (CNS), the integrity of brain extracelluar matrix (ECM), oxidative stress and dysfunction in neuronal transmission may contribute to the observed pathology. The purpose of this study was to investigate the role of these factors in demyelinating canine distemper virus (CDV) infections. Regardless of ECM integrity, the expression of metalloproteinase-9 (MMP-9) was visualized in microglial-like cells, whereas the expression of anti-oxidant like-1 (AOP-1) and synaptosomal associated protein (SNAP-25) was frequently detected in Purkinje cells (r2 = 0.989; p < 0.05), regardless of whether the lesions were classified as acute or chronic. Increased numbers of immunolabeled microglia-like cells and reactive gliosis were observed in advanced cases of demyelinating CDV, suggesting that the expression of AOP-1 and SNAP-25 is correlated with the ultimate death of affected cells. Our findings bring a new perspective to understanding the role of the AOP-1, MMP-9 and SNAP-25 proteins in mediating chronic leukoencephalitis caused by CDV. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 41–48)en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Cirurgia e Reprodução Animal, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Apoio a Produção e Saúde Animal, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Cirurgia e Reprodução Animal, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Apoio a Produção e Saúde Animal, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação Amparo à Pesquisa Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 472226/2007–0
dc.description.sponsorshipIdFAPESP: 2008/03802–2
dc.format.extent41-48
dc.identifierhttp://dx.doi.org/10.5603/FHC.2011.0007
dc.identifier.citationFolia Histochemica et Cytobiologica, v. 49, n. 1, p. 41-48, 2011.
dc.identifier.doi10.5603/FHC.2011.0007
dc.identifier.issn0239-8508
dc.identifier.lattes4457513019131365
dc.identifier.lattes4272904699684196
dc.identifier.lattes8571130051947425
dc.identifier.lattes1132889819408130
dc.identifier.lattes4584674909952477
dc.identifier.urihttp://hdl.handle.net/11449/133123
dc.language.isoeng
dc.relation.ispartofFolia Histochemica et Cytobiologica
dc.relation.ispartofjcr1.586
dc.relation.ispartofsjr0,586
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectCDVen
dc.subjectAntioxidative stressen
dc.subjectProtein expressionen
dc.titleImmunohistochemical detection of metalloproteinase-9 (MMP-9), anti-oxidant like 1 protein (AOP-1) and synaptosomal-associated protein (SNAP-25) in the cerebella of dogs naturally infected with spontaneous canine distemperen
dc.typeArtigo
unesp.author.lattes4457513019131365
unesp.author.lattes4272904699684196
unesp.author.lattes8571130051947425
unesp.author.lattes1132889819408130
unesp.author.lattes4584674909952477
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.departmentClínica Cirurgia e Reprodução Animalpt
unesp.departmentApoio a Produção e Saúde Animalpt

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Artigos - Apoio, Produção e Saúde Animal - FMVA