Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species

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dc.contributor.authorVellosa, José Carlos Rebuglio
dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorBelló, Caroline
dc.contributor.authorSchemberger, Josiane Aparecida
dc.contributor.authorKhalil, Najeh Maissar
dc.contributor.authorMorandim-Giannetti, Andreia De Araújo
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorOliveira, Olga Maria Mascarenhas de Faria [UNESP]
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual do Centro Oeste (UNICENTRO)
dc.contributor.institutionCentro Universitário da FEI
dc.date.accessioned2015-04-27T11:56:08Z
dc.date.available2015-04-27T11:56:08Z
dc.date.issued2014
dc.description.abstractBiological activities of flavonoids have been extensively reviewed in literature. The biochemical profile of afzelin, kaempferitrin, and pterogynoside acting on reactive oxygen species was investigated in this paper. The flavonoids were able to act as scavengers of the superoxide anion, hypochlorous acid and taurine chloramine. Although flavonoids are naturally occurring substances in plants which antioxidant activities have been widely advertised as beneficial, afzelin, kaempferitrin, and pterogynoside were able to promote cytotoxic effect. In red blood cells this toxicity was enhanced, depending on flavonoids concentration, in the presence of hypochlorous acid, but reduced in the presence of 2,20 -azo-bis(2-amidinopropane) free radical. These flavonoids had also promoted the death of neutrophils, which was exacerbated when the oxidative burst was initiated by phorbol miristate acetate. Therefore, despite their well-known scavenging action toward free radicals and oxidants, these compounds could be very harmful to living organisms through their action over erythrocytes and neutrophils.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil
dc.description.affiliationUnespDepartamento de Química Orgânica, Instituto de Química de Araraquara, Universidade Estadual Paulista, Araraquara, SP, Brazil
dc.description.affiliationUnespDepartamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, SP, Brazil
dc.description.affiliationUnespDepartamento de Bioquímica e Tecnologia Química, Instituto de Química de Araraquara, Universidade Estadual Paulista (UNESP), Rua Francisco Degni, 55, P.O. Box: 14800-900, Araraquara, SP, Brazil
dc.identifierhttp://link.springer.com/article/10.1007%2Fs12272-014-0487-1
dc.identifier.citationArchives of Pharmacal Research, 2014.
dc.identifier.doi10.1007/s12272-014-0487-1
dc.identifier.issn0253-6269
dc.identifier.lattes4484083685251673
dc.identifier.lattes1522293867934005
dc.identifier.lattes0992736452764550
dc.identifier.lattes8578241611510102
dc.identifier.urihttp://hdl.handle.net/11449/122910
dc.language.isoeng
dc.relation.ispartofArchives of Pharmacal Research
dc.relation.ispartofjcr2.330
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectFlavonoidsen
dc.subjectRed blood cells lysisen
dc.subjectOxidative bursten
dc.subjectAntioxidantsen
dc.subjectPterogyne nitensen
dc.subjectFree radicalsen
dc.subjectInten
dc.titlePreliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen speciesen
dc.typeArtigo
unesp.author.lattes4484083685251673
unesp.author.lattes1522293867934005
unesp.author.lattes0992736452764550
unesp.author.lattes8578241611510102
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentQuímica e Ciências Ambientaispt

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