Multifunctional antitumor magnetite/chitosan-l-glutamic acid (core/shell) nanocomposites

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dc.contributor.authorSantos, Daniela P. [UNESP]
dc.contributor.authorRuiz, Miguel [UNESP]
dc.contributor.authorGallardo, Visitacion
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.authorArias, Jose L.
dc.contributor.institutionUniv Granada
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:19:16Z
dc.date.available2014-05-20T14:19:16Z
dc.date.issued2011-09-01
dc.description.abstractThe development of anticancer drug delivery systems based on biodegradable nanoparticles has been intended to maximize the localization of chemotherapy agents within tumor interstitium, along with negligible drug distribution into healthy tissues. Interestingly, passive and active drug targeting strategies to cancer have led to improved nanomedicines with great tumor specificity and efficient chemotherapy effect. One of the most promising areas in the formulation of such nanoplatforms is the engineering of magnetically responsive nanoparticles. In this way, we have followed a chemical modification method for the synthesis of magnetite/chitosan-l-glutamic acid (core/shell) nanostructures. These magnetic nanocomposites (average size a parts per thousand 340 nm) exhibited multifunctional properties based on its capability to load the antitumor drug doxorubicin (along with an adequate sustained release) and its potential for hyperthermia applications. Compared to drug surface adsorption, doxorubicin entrapment into the nanocomposites matrix yielded a higher drug loading and a slower drug release profile. Heating characteristics of the magnetic nanocomposites were investigated in a high-frequency alternating magnetic gradient: a stable maximum temperature of 46 A degrees C was successfully achieved within 40 min. To our knowledge, this is the first time that such kind of stimuli-sensitive nanoformulation with very important properties (i.e., magnetic targeting capabilities, hyperthermia, high drug loading, and little burst drug release) has been formulated for combined antitumor therapy against cancer.en
dc.description.affiliationUniv Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain
dc.description.affiliationUNESP, Univ São Paulo State, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Univ São Paulo State, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipJunta de Andalucia
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdJunta de Andalucia: PE2008-FQM-3993
dc.description.sponsorshipIdFAPESP: 07/07914-7
dc.format.extent4311-4323
dc.identifierhttp://dx.doi.org/10.1007/s11051-011-0378-z
dc.identifier.citationJournal of Nanoparticle Research. Dordrecht: Springer, v. 13, n. 9, p. 4311-4323, 2011.
dc.identifier.doi10.1007/s11051-011-0378-z
dc.identifier.issn1388-0764
dc.identifier.lattes7875454594123419
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.urihttp://hdl.handle.net/11449/25812
dc.identifier.wosWOS:000293773700066
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Nanoparticle Research
dc.relation.ispartofjcr2.127
dc.relation.ispartofsjr0,528
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBiodegradable nanoparticleen
dc.subjectCanceren
dc.subjectDoxorubicinen
dc.subjectHyperthermiaen
dc.subjectMagnetically responsive drug nanocarrieren
dc.subjectMultifunctional nanoformulationen
dc.subjectNanomedicineen
dc.titleMultifunctional antitumor magnetite/chitosan-l-glutamic acid (core/shell) nanocompositesen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes7875454594123419
unesp.author.orcid0000-0002-2296-1393[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Analítica - IQ