Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?

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dc.contributor.authorFernandes, Glaura S. A.
dc.contributor.authorGerardin, Daniela C. C.
dc.contributor.authorAssumpção, Thaiane A. [UNESP]
dc.contributor.authorCampos, Kleber E. [UNESP]
dc.contributor.authorDamasceno, Débora C. [UNESP]
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.authorKempinas, Wilma D. G. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T01:01:42Z
dc.date.available2022-04-29T01:01:42Z
dc.date.issued2011-01-01
dc.description.abstractDiabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic adult male rats. The animals were randomly assigned to one of four experimental groups: hyperglycemic control (Hy), hyperglycemic + 150 mg/day vitamin C (HyC), hyperglycemic + 100 mg/day vitamin E (HyE) or hyperglycemic + vitamins C and E (HyCE). The normoglycemic group (n = 10) received only the vehicles. The testosterone level and noradrenergic response of the vas deferens were analyzed. Both vitamins significantly decreased the TBARS (thiobarbituric acid reactive species) level in the hyperglycemic groups. There was a significant reduction in the testosterone level in the Hy and HyE groups when compared to the normoglycemic group. However, the testosterone levels were partially recovered in the HyC and HyCE groups. In addition, an increased sensitivity of the α-1 adrenoceptor in the vas deferens of the hyperglycemic control group was observed. Treatment with vitamins partially restored (vitamin E or in combination with vitamin C) or totally (vitamin C alone) this dysfunction. Moreover, the maximum response values to norepinephrine were similar among all groups. Thus, we concluded that vitamin C is more efficient than vitamin E in attenuating the effects of hyperglycemia on the male reproductive system of adult rats. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.en
dc.description.affiliationInstitute of Biology State University of Campinas -UNICAMP Cidade Universitária Zeferino Vaz, 13083-862, Campinas, SP
dc.description.affiliationDepartment of Physiological Sciences State University of Londrina Londrina - UEL, Celso Garcia Cid, 86051-980, Londrina, PR
dc.description.affiliationDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, Distrito de Rubião Jr. s/n, 18618-000, Botucatu, SP
dc.format.extent983-991
dc.identifierhttp://dx.doi.org/10.1016/S1734-1140(11)70614-4
dc.identifier.citationPharmacological Reports, v. 63, n. 4, p. 983-991, 2011.
dc.identifier.doi10.1016/S1734-1140(11)70614-4
dc.identifier.issn1734-1140
dc.identifier.scopus2-s2.0-80053357348
dc.identifier.urihttp://hdl.handle.net/11449/226539
dc.language.isoeng
dc.relation.ispartofPharmacological Reports
dc.sourceScopus
dc.subjectHyperglycemia
dc.subjectMale rat
dc.subjectMale reproductive system
dc.subjectNorepinephrine
dc.subjectTestosterone
dc.subjectVas deferens
dc.subjectVitamin C
dc.subjectVitamin E
dc.titleCan vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?en
dc.typeArtigo

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