Neurological manifestations by sex and age group in COVID-19 inhospital patients

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dc.contributor.authorPereira, Daniella Nunes
dc.contributor.authorBicalho, Maria Aparecida Camargos
dc.contributor.authorJorge, Alzira de Oliveira
dc.contributor.authorGomes, Angélica Gomides dos Reis
dc.contributor.authorSchwarzbold, Alexandre Vargas
dc.contributor.authorAraújo, Anna Luiza Homan
dc.contributor.authorCimini, Christiane Corrêa Rodrigues
dc.contributor.authorPonce, Daniela [UNESP]
dc.contributor.authorRios, Danyelle Romana Alves
dc.contributor.authorGrizende, Genna Maira Santos
dc.contributor.authorManenti, Euler Roberto Fernandes
dc.contributor.authorAnschau, Fernando
dc.contributor.authorAranha, Fernando Graça
dc.contributor.authorBartolazzi, Frederico
dc.contributor.authorBatista, Joanna d'Arc Lyra
dc.contributor.authorTupinambás, Julia Teixeira
dc.contributor.authorRuschel, Karen Brasil
dc.contributor.authorFerreira, Maria Angélica Pires
dc.contributor.authorParaíso, Pedro Gibson
dc.contributor.authorAraújo, Silvia Ferreira
dc.contributor.authorTeixeira, Antonio Lucio
dc.contributor.authorMarcolino, Milena Soriano
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionFundação Hospitalar do Estado de Minas Gerais (Fhemig)
dc.contributor.institutionHospital Risoleta Tolentino Neves
dc.contributor.institutionHospitais da Rede Mater Dei
dc.contributor.institutionUniversidade Federal de Santa Maria
dc.contributor.institutionHospital Universitário Ciências Médicas
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São João del-Rei
dc.contributor.institutionSanta Casa de Misericórdia de Belo Horizonte
dc.contributor.institutionHospital Mãe de Deus
dc.contributor.institutionHospital Nossa Senhora da Conceição and Hospital Cristo Redentor
dc.contributor.institutionHospital SOS Cárdio
dc.contributor.institutionHospital Santo Antônio
dc.contributor.institutionUniversidade Federal Fronteira do Sul
dc.contributor.institutionHospital Metropolitano Odilon Behrens
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
dc.contributor.institutionIATS/CnPq
dc.contributor.institutionOrizonti- Instituto Oncomed de Saúde e Longevidade
dc.contributor.institutionHospital Semper
dc.contributor.institutionFaculdade Santa Casa BH
dc.contributor.institutionInstitute for Health Technology Assessment (IATS/ CNPq)
dc.contributor.institutionInstituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
dc.contributor.institutionHospital Regional do Oeste
dc.contributor.institutionUT Health Houston
dc.date.accessioned2023-03-01T21:08:02Z
dc.date.available2023-03-01T21:08:02Z
dc.date.issued2022-09-01
dc.description.abstractIntroduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.en
dc.description.affiliationFaculdade de Medicina Universidade Federal de Minas Gerais
dc.description.affiliationFundação Hospitalar do Estado de Minas Gerais (Fhemig)
dc.description.affiliationHospital Risoleta Tolentino Neves
dc.description.affiliationHospitais da Rede Mater Dei
dc.description.affiliationHospital Universitário de Santa Maria/EBSERH Universidade Federal de Santa Maria
dc.description.affiliationHospital Universitário Ciências Médicas
dc.description.affiliationHospital Santa Rosália
dc.description.affiliationHospital das Clínicas da Faculdade de Medicina de Botucatu
dc.description.affiliationComplexo da Saúde São João de Deus Universidade Federal de São João del-Rei
dc.description.affiliationSanta Casa de Misericórdia de Belo Horizonte
dc.description.affiliationHospital Mãe de Deus
dc.description.affiliationGrupo Hospitalar Conceição Brazilian National Health System Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor
dc.description.affiliationHospital SOS Cárdio
dc.description.affiliationHospital Santo Antônio
dc.description.affiliationUniversidade Federal Fronteira do Sul
dc.description.affiliationHospital Metropolitano Odilon Behrens
dc.description.affiliationHospital Mãe de Deus Hospital Universitário de Canoas Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
dc.description.affiliationHospital de Clínicas de Porto Alegre IATS/CnPq
dc.description.affiliationOrizonti- Instituto Oncomed de Saúde e Longevidade
dc.description.affiliationHospital Semper
dc.description.affiliationFaculdade Santa Casa BH
dc.description.affiliationDepartment of Internal Medicine Medical School and Telehealth Center University Hospital Universidade Federal de Minas Gerais
dc.description.affiliationUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
dc.description.affiliationInstitute for Health Technology Assessment (IATS/ CNPq)
dc.description.affiliationCampus Centro Oeste Dona Lindu Universidade Federal de São João del-Rei
dc.description.affiliationInstituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
dc.description.affiliationHospital Regional do Oeste
dc.description.affiliationNeuropsychiatry Program Department of Psychiatry and Behavioral Sciences UT Health Houston
dc.description.affiliationUnespHospital das Clínicas da Faculdade de Medicina de Botucatu
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 147122/2021–0
dc.description.sponsorshipIdCNPq: 310561/2021–3
dc.identifierhttp://dx.doi.org/10.1016/j.ensci.2022.100419
dc.identifier.citationeNeurologicalSci, v. 28.
dc.identifier.doi10.1016/j.ensci.2022.100419
dc.identifier.issn2405-6502
dc.identifier.scopus2-s2.0-85136248005
dc.identifier.urihttp://hdl.handle.net/11449/241525
dc.language.isoeng
dc.relation.ispartofeNeurologicalSci
dc.sourceScopus
dc.subjectAge
dc.subjectCOVID-19
dc.subjectDelirium
dc.subjectNeurological manifestations
dc.subjectSex
dc.titleNeurological manifestations by sex and age group in COVID-19 inhospital patientsen
dc.typeArtigo

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