Diet-induced obesity in rats leads to a decrease in sperm motility

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dc.contributor.authorFernandez, Carla D. B. [UNESP]
dc.contributor.authorBellentani, Fernanda F. [UNESP]
dc.contributor.authorFernandes, Glaura S. A. [UNESP]
dc.contributor.authorPerobelli, Juliana E. [UNESP]
dc.contributor.authorFavareto, Ana Paula A. [UNESP]
dc.contributor.authorNascimento, Andre F. [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorKempinas, Wilma D. G. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:27Z
dc.date.available2014-05-20T13:33:27Z
dc.date.issued2011-03-11
dc.description.abstractBackground: Obesity is rapidly becoming a worldwide epidemic that affects children and adults. Some studies have shown a relationship between obesity and infertility, but until now it remains controversial. Thus, the aim of the present study was to investigate the effect of high-fat diet-induced obesity on male reproductive parameters.Methods: In a first experiment, male Wistar rats were fed a high-fat diet (HFD) or standard chow (SD) for 15, 30 or 45 weeks, after which they were evaluated by adiposity index, serum leptin levels, reproductive organ weights and sperm counts. In a second experiment, rats received HFD or SD only for 15 weeks, long enough to cause obesity. Sexual hormones and sexual behavior were evaluated in these animals, as well as fertility after natural mating. Another group of rats was submitted to motility analysis and fertility evaluation after in utero insemination.Results: After 15, 30 or 45 weeks, HFD-fed animals presented significant increases in obesity index and serum leptin levels. Reproductive organ weights and sperm counts in the testis and epididymis were similar between the two groups at all timepoints studied. Sexual behavior was not altered by the diet regimen, and HFD fertility after natural mating was also similar to SD-fed animals. Intergroup testosterone levels were also comparable, but estradiol levels were increased in HFD rats. Furthermore, sperm quality was reduced in HFD animals as evidenced by their decreased percentage of sperm with progressive movement. This altered motility parameter was followed by a trend toward reduction in fertility potential after artificial in utero insemination.Conclusions: The results reported herein showed that obesity can affect sperm quality, by reducing sperm motility, without affecting other sperm parameters. The low sperm quality caused a slight reduction in fertility potential, showing that obesity may lead to impairment in male fertility.en
dc.description.affiliationUniv Campinas UNICAMP, Grad Program Cell & Struct Biol, Inst Biol, Campinas, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Clin Med, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Clin Med, Botucatu Med Sch, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1186/1477-7827-9-32
dc.identifier.citationReproductive Biology and Endocrinology. London: Biomed Central Ltd., v. 9, p. 10, 2011.
dc.identifier.doi10.1186/1477-7827-9-32
dc.identifier.fileWOS000288967700001.pdf
dc.identifier.issn1477-7827
dc.identifier.lattes9418970103564137
dc.identifier.urihttp://hdl.handle.net/11449/11469
dc.identifier.wosWOS:000288967700001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofReproductive Biology and Endocrinology
dc.relation.ispartofjcr2.852
dc.relation.ispartofsjr1,203
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleDiet-induced obesity in rats leads to a decrease in sperm motilityen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.author.lattes9418970103564137[7]
unesp.author.orcid0000-0002-0940-5894[1]
unesp.author.orcid0000-0002-4402-6523[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Morfologia - IBB
Artigos - Clínica Médica - FMB