Crystal structure of human PNP complexed with hypoxanthine and sulfate ion
dc.contributor.author | Canduri, F. | |
dc.contributor.author | Fadel, V | |
dc.contributor.author | Dias, MVB | |
dc.contributor.author | Basso, L. A. | |
dc.contributor.author | Palma, Mario Sergio [UNESP] | |
dc.contributor.author | Santos, D. S. | |
dc.contributor.author | de Azevedo, W. F. | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Instituto Butantan | |
dc.contributor.institution | Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) | |
dc.date.accessioned | 2014-05-20T13:54:25Z | |
dc.date.available | 2014-05-20T13:54:25Z | |
dc.date.issued | 2005-01-14 | |
dc.description.abstract | Purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme, which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function. Human PNP has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Here we report the crystal structure of human PNP in complex with hypoxanthine, refined to 2.6 Angstrom resolution. The intermolecular interaction between ligand and PNP is discussed. (C) 2004 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | UFRGS, Dept Mol Biol & Biotechnol, BR-91501970 Porto Alegre, RS, Brazil | |
dc.description.affiliation | UNESP, Programa Posgraduacao Biofis Mol, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliation | Inst Butantan, Ctr Appl Toxinol, BR-05503900 São Paulo, Brazil | |
dc.description.affiliation | UNESP, Lab Struct Biol & Zoochem, CEIS, Dept Biol,Inst Biosci, BR-13506900 Rio Claro, SP, Brazil | |
dc.description.affiliation | PUCRS, Ctr Pesquisas Biol Mol & Func, Inst Pesquisas Biomed, BR-90619900 Porto Alegre, RS, Brazil | |
dc.description.affiliationUnesp | UNESP, Programa Posgraduacao Biofis Mol, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, Lab Struct Biol & Zoochem, CEIS, Dept Biol,Inst Biosci, BR-13506900 Rio Claro, SP, Brazil | |
dc.format.extent | 335-338 | |
dc.identifier | http://dx.doi.org/10.1016/j.bbrc.2004.11.038 | |
dc.identifier.citation | Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 326, n. 2, p. 335-338, 2005. | |
dc.identifier.doi | 10.1016/j.bbrc.2004.11.038 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.lattes | 2835029061696580 | |
dc.identifier.lattes | 2901888624506535 | |
dc.identifier.uri | http://hdl.handle.net/11449/19455 | |
dc.identifier.wos | WOS:000225997300011 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | |
dc.relation.ispartofjcr | 2.559 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | PNP | pt |
dc.subject | synchrotron radiation | pt |
dc.subject | Structure | pt |
dc.subject | drug design | pt |
dc.subject | hypoxanthine | pt |
dc.title | Crystal structure of human PNP complexed with hypoxanthine and sulfate ion | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 2835029061696580 | |
unesp.author.lattes | 2901888624506535 | |
unesp.author.orcid | 0000-0002-5312-0191[3] | |
unesp.author.orcid | 0000-0001-6368-8955[2] | |
unesp.author.orcid | 0000-0002-7363-8211[5] | |
unesp.author.orcid | 0000-0003-4971-463X[6] | |
unesp.author.orcid | 0000-0003-0903-2407[4] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claro | pt |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Biologia - IB | pt |
unesp.department | Física - IBILCE | pt |
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