Crystal structure of human PNP complexed with hypoxanthine and sulfate ion

dc.contributor.authorCanduri, F.
dc.contributor.authorFadel, V
dc.contributor.authorDias, MVB
dc.contributor.authorBasso, L. A.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorSantos, D. S.
dc.contributor.authorde Azevedo, W. F.
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
dc.date.accessioned2014-05-20T13:54:25Z
dc.date.available2014-05-20T13:54:25Z
dc.date.issued2005-01-14
dc.description.abstractPurine nucleoside phosphorylase (PNP) is a ubiquitous enzyme, which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function. Human PNP has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Here we report the crystal structure of human PNP in complex with hypoxanthine, refined to 2.6 Angstrom resolution. The intermolecular interaction between ligand and PNP is discussed. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUFRGS, Dept Mol Biol & Biotechnol, BR-91501970 Porto Alegre, RS, Brazil
dc.description.affiliationUNESP, Programa Posgraduacao Biofis Mol, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationInst Butantan, Ctr Appl Toxinol, BR-05503900 São Paulo, Brazil
dc.description.affiliationUNESP, Lab Struct Biol & Zoochem, CEIS, Dept Biol,Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationPUCRS, Ctr Pesquisas Biol Mol & Func, Inst Pesquisas Biomed, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliationUnespUNESP, Programa Posgraduacao Biofis Mol, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Lab Struct Biol & Zoochem, CEIS, Dept Biol,Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent335-338
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2004.11.038
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 326, n. 2, p. 335-338, 2005.
dc.identifier.doi10.1016/j.bbrc.2004.11.038
dc.identifier.issn0006-291X
dc.identifier.lattes2835029061696580
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19455
dc.identifier.wosWOS:000225997300011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.ispartofjcr2.559
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPNPpt
dc.subjectsynchrotron radiationpt
dc.subjectStructurept
dc.subjectdrug designpt
dc.subjecthypoxanthinept
dc.titleCrystal structure of human PNP complexed with hypoxanthine and sulfate ionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2835029061696580
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0002-5312-0191[3]
unesp.author.orcid0000-0001-6368-8955[2]
unesp.author.orcid0000-0002-7363-8211[5]
unesp.author.orcid0000-0003-4971-463X[6]
unesp.author.orcid0000-0003-0903-2407[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBpt
unesp.departmentFísica - IBILCEpt

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