Pharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology

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dc.contributor.authorNascimento, Maria Carolina M. O. [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorCorrêa, Camila Renata [UNESP]
dc.contributor.authorPereira, Elenize J. [UNESP]
dc.contributor.authorMoreira, Priscila L. [UNESP]
dc.contributor.authorCarvalho, Flavio A. [UNESP]
dc.contributor.authorBurini, Caio H. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorYeum, Kyung-Jin
dc.contributor.authorFerreira, Ana Lúcia dos Anjos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts Univ
dc.date.accessioned2014-05-20T13:48:05Z
dc.date.available2014-05-20T13:48:05Z
dc.date.issued2011-10-01
dc.description.abstractThe effect of pharmacological dose of cc-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = II) or E (cc-tocopherol, n = II) group. Animals received corn oil (C) or alpha-tocopherol dissolved in corn oil (250 mg alpha-tocopherol/[kg body wt/day]) (E) by gavage for a 7-week period. Rats underwent echocardiogram and were analyzed for cardiomyocyte histology and cardiac cc-tocopherol absorption at the end of the study period. As compared to the C group, alpha-tocopherol-supplemented group showed significantly (p < 0.05) lower body weight (E, 412.8 g vs C, 480.3 g) and total cardiac weight (E, 0.94 g vs C, 1.08 g); cardiomyocyte histological impairment; smaller left ventricle (LV) (LV end-diastolic diameter (E, 7.22 mm vs C, 7.37 mm), lower LV systolic [left ventricle fractional shortening (E, 47.6% vs C, 53.6%) and ejection fraction ratio (E, 85.4 vs C, 89.9)] and diastolic [early peak velocities of diastolic transmitral flow (E, 64.6 cm/sec vs C, 75.1 cm/sec)] function. The alpha-tocopherol uptake in target tissue was confirmed by determination of alpha-tocopherol concentration medians in cardiac tissue (E, 109.91 nmol/kg vs C, 52.09 nmol/kg). The current study indicates that pharmacological dose of alpha-tocopherol supplementation can induce cardiotoxicity in healthy rats.en
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Sch Med, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Vet Med, Dept Vet Pathol, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biociencias, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationTufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Sch Med, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Vet Med, Dept Vet Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biociencias, Dept Biostat, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 05/52571-5
dc.description.sponsorshipIdCNPq: 301943/2007-9
dc.format.extent1540-1548
dc.identifierhttp://dx.doi.org/10.1177/0960327110392401
dc.identifier.citationHuman & Experimental Toxicology. London: Sage Publications Ltd, v. 30, n. 10, p. 1540-1548, 2011.
dc.identifier.doi10.1177/0960327110392401
dc.identifier.issn0960-3271
dc.identifier.lattes6990977122340795
dc.identifier.lattes8727897080522289
dc.identifier.lattes6309835137998766
dc.identifier.lattes2940051650846541
dc.identifier.urihttp://hdl.handle.net/11449/17142
dc.identifier.wosWOS:000295812200013
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.ispartofjcr1.840
dc.relation.ispartofsjr0,559
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalpha-tocopherolen
dc.subjectcardiotoxicityen
dc.subjectraten
dc.subjectDoppler-echocardiogramen
dc.titlePharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histologyen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
unesp.author.lattes6990977122340795
unesp.author.lattes8727897080522289[9]
unesp.author.lattes6309835137998766
unesp.author.lattes2940051650846541[11]
unesp.author.orcid0000-0002-7719-9682[9]
unesp.author.orcid0000-0002-5267-1127[11]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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