Absence of mutagenicity effects of Psidium cattleyanum Sabine (Myrtaceae) extract on peripheral blood and bone marrow cells of mice

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dc.contributor.authorCosta, T. D. A. [UNESP]
dc.contributor.authorVieira, S. [UNESP]
dc.contributor.authorAndrade, S. F.
dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Vale Itajai
dc.date.accessioned2014-05-20T13:31:43Z
dc.date.available2014-05-20T13:31:43Z
dc.date.issued2008-01-01
dc.description.abstractCattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at concentrations of 1000, 1500 and 2000 mg/kg. N-nitroso-N-ethylurea was used as a positive control. Peripheral blood leukocytes were collected 4 and 24 h after the treatments for the comet assay, and bone marrow cells were collected after 24 and 48 h for the micronucleus test. Unlike N-nitroso-N-ethylurea, P. cattleyanum extract failed to induce a significant increase in cell DNA damage, in micronucleated cell frequency, and in bone marrow toxicity. The lack of mutagenicity and cytotoxicity with high doses of this plant extract means that it can be safely used in traditional medicine.en
dc.description.affiliationUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.affiliationUniv Vale Itajai, Nucleo Invest Quimicofarmaceut, Itajai, SC, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 306544/2006-7
dc.description.sponsorshipIdFAPESP: 06/57514-2
dc.format.extent679-686
dc.identifierhttp://dx.doi.org/10.4238/vol7-3gmr475
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 7, n. 3, p. 679-686, 2008.
dc.identifier.doi10.4238/vol7-3gmr475
dc.identifier.fileWOS000260227100011.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
dc.identifier.urihttp://hdl.handle.net/11449/10806
dc.identifier.wosWOS:000260227100011
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPsidium cattleyanumen
dc.subjectComet assayen
dc.subjectMicronucleus testen
dc.subjectSingle-cell gel electrophoresisen
dc.subjectMutagenesisen
dc.titleAbsence of mutagenicity effects of Psidium cattleyanum Sabine (Myrtaceae) extract on peripheral blood and bone marrow cells of miceen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes4787521613038315[4]
unesp.author.orcid0000-0003-0757-7876[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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Artigos - Fonoaudiologia - FFC