Genotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivo

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dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.contributor.authorMota, S. F.
dc.contributor.authorLima, E. B.
dc.contributor.authorBernardes, B. M.
dc.contributor.authorGoulart, F. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Jose do Rosario Vellano UNIFENAS
dc.date.accessioned2014-05-20T13:31:44Z
dc.date.available2014-05-20T13:31:44Z
dc.date.issued2010-01-01
dc.description.abstractRosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oil of R. officinalis in rodents, using comet, micronucleus and chromosome aberration assays. The animals were treated by gavage with one of three dosages of rosemary oil (300, 1000 or 2000 mg/kg). Liver and peripheral blood cells were collected from Swiss mice 24 h after treatment for the comet assay (genotoxicity endpoint), along with bone marrow cells for the micronucleus test (mutagenicity endpoint). Bone marrow cells were collected from Wistar rats 24 h after oil treatment for the micronucleus and chromosome aberration assays. Based on the comet assay, all three doses of rosemary oil induced significant increases in DNA damage in the mouse cells. There was a significant increase in micronucleated cells and chromosome aberrations only at the two higher doses. We conclude that rosemary essential oil provokes genotoxic and mutagenic effects when administered orally.en
dc.description.affiliationUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.affiliationUniv Jose do Rosario Vellano UNIFENAS, Fac Farm & Biomed, Alfenas, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCNPq: 306544/2006-7
dc.description.sponsorshipIdFAPESP: 06/57514-2
dc.description.sponsorshipIdFAPEMIG: 1879/02
dc.format.extent2113-2122
dc.identifierhttp://dx.doi.org/10.4238/vol9-4gmr857
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 9, n. 4, p. 2113-2122, 2010.
dc.identifier.doi10.4238/vol9-4gmr857
dc.identifier.fileWOS000284324400012.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
dc.identifier.urihttp://hdl.handle.net/11449/10811
dc.identifier.wosWOS:000284324400012
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectChromosome aberrationsen
dc.subjectComet assayen
dc.subjectEssential oilen
dc.subjectMicronucleus testen
dc.subjectRosmarinus officinalisen
dc.titleGenotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivoen
dc.typeResumo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes4787521613038315[1]
unesp.author.orcid0000-0003-4104-8791[5]
unesp.author.orcid0000-0003-0757-7876[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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Artigos - Fonoaudiologia - FFC