Immunohistochemistry of small blue round cell tumors

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dc.contributor.authorGown, Allen M.
dc.contributor.authorBacchi, Carlos E. [UNESP]
dc.contributor.institutionPhenoPath Laboratories
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:55:38Z
dc.date.available2022-04-28T19:55:38Z
dc.date.issued2002-01-01
dc.description.abstractSmall blue round cell tumors (SBRCTs) are a set of malignancies that have a particular proclivity for the pediatric age group. These tumors are notoriously difficult to distinguish by histologic evaluation alone, and in recent years a number of new immunohistochemical markers have emerged that can aid in the correct categorization of these lesions. Myogenin, a muscle-restricted nuclear transcription factor, has been demonstrated to be a highly sensitive and specific marker of rhabdomyosarcoma, and is superior to previous markers such as myoglobin, muscle actins, and desmin. The FII-I gene product is expressed as part of the EWS/FLI-1 novel chimeric protein that results from the t(11;22)(q24;q12) translocation that occurs in approximately two-thirds of cases of PNET/Ewings sarcoma. Immunohistochemical detection of the FLI-1 gene product can thus complement detection of CD99/MIC2 for the positive identification of PNET/Ewings sarcoma. Markers of neuroblastoma include neural markers, such as chromogranin A, neurofilaments, and synaptophysin. Desmoplastic small round cell tumor (DSRCT) is a tumor with an unusual immunophenotype, including co-expression of cytokeratin, vimentin, and desmin; recent studies have also documented the use of antibodies to the WT-1 gene product as a marker of the chimeric EWS/WT-1 protein formed as a result of the t(11;22)(p13;q12) translocation that characterizes this unique tumor. In summary, there now exists a panel of antibodies defining immunohistochemical markers of individual SBRCTs that can identify rhabdomyosarcoma, PNET/Ewings sarcoma, neuroblastoma, and DSRCT with high sensitivity and specificity.en
dc.description.affiliationPhenoPath Laboratories, Seattle, WA
dc.description.affiliationDepartment of Pathology UNESP - Botucatu, Botucatu - SP
dc.description.affiliationUnespDepartment of Pathology UNESP - Botucatu, Botucatu - SP
dc.format.extent229-234
dc.identifierhttp://dx.doi.org/10.1179/his.2002.25.4.229
dc.identifier.citationJournal of Histotechnology, v. 25, n. 4, p. 229-234, 2002.
dc.identifier.doi10.1179/his.2002.25.4.229
dc.identifier.issn0147-8885
dc.identifier.scopus2-s2.0-0036943280
dc.identifier.urihttp://hdl.handle.net/11449/224290
dc.language.isoeng
dc.relation.ispartofJournal of Histotechnology
dc.sourceScopus
dc.titleImmunohistochemistry of small blue round cell tumorsen
dc.typeResenha

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