Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

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dc.contributor.authorSeiva, Fabio R. F. [UNESP]
dc.contributor.authorChuffa, Luiz Gustavo A. [UNESP]
dc.contributor.authorBraga, Camila Pereira [UNESP]
dc.contributor.authorAmorim, Joao Paulo A.
dc.contributor.authorFernandes, Ana Angelica H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:47:30Z
dc.date.available2014-05-20T13:47:30Z
dc.date.issued2012-10-01
dc.description.abstractWe reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP Univ State São Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ State São Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP, Brazil
dc.description.affiliationUNICAMP Univ Campinas, Inst Biol, Dept Anat Cellular Biol Physiol & Biophys, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP Univ State São Paulo, Dept Chem & Biochem, Inst Biosci, Unesp Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ State São Paulo, Dept Anat, Inst Biosci, Unesp Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 02/03359-5
dc.format.extent3556-3561
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2012.07.009
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 10, p. 3556-3561, 2012.
dc.identifier.doi10.1016/j.fct.2012.07.009
dc.identifier.fileWOS000309897100025.pdf
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/11449/16909
dc.identifier.wosWOS:000309897100025
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMonosodium glutamateen
dc.subjectLipid profileen
dc.subjectMetabolismen
dc.subjectQuercetinen
dc.subjectHepatoprotectionen
dc.subjectAntioxidant defensesen
dc.titleQuercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterationsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.orcid0000-0002-7461-8773[1]
unesp.author.orcid0000-0002-0199-3396[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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