Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

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dc.contributor.authorSerrano, Maria A. R. [UNESP]
dc.contributor.authorPivatto, Marcos [UNESP]
dc.contributor.authorFrancisco, Welington [UNESP]
dc.contributor.authorDanuello, Amanda [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorLopes, Elaine M. C.
dc.contributor.authorLopes, Márcia Nasser [UNESP]
dc.contributor.authorYoung, Maria C. M.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Bot
dc.date.accessioned2014-05-20T14:20:14Z
dc.date.available2014-05-20T14:20:14Z
dc.date.issued2010-03-01
dc.description.abstractTwo unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone none (2), were isolated front the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established oil the basis of spectroscopy data interpretation. Compounds I and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison With the standard compound physostiomine.en
dc.description.affiliationUNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationInst Bot, Dept Organ Chem, Inst Chem, NuBBE Nat Prod, BR-01061970 São Paulo, Brazil
dc.description.affiliationInst Bot, Sect Plant Biochem & Physiol, BR-01061970 São Paulo, Brazil
dc.description.affiliationUnespUNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBiodiversity Virtual Institute
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdBiodiversity Virtual Institute: 03/02176-7
dc.format.extent482-484
dc.identifierhttp://dx.doi.org/10.1021/np900644x
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 73, n. 3, p. 482-484, 2010.
dc.identifier.doi10.1021/np900644x
dc.identifier.issn0163-3864
dc.identifier.lattes3310170899693944
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/26079
dc.identifier.wosWOS:000275885000036
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAcetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijugaen
dc.typeResumo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes3310170899693944
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Orgânica - IQ