The universal growth rate behavior and regime transition in adherent cell colonies

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dc.contributor.authorCosta, F. H. S.
dc.contributor.authorCampos, M. [UNESP]
dc.contributor.authorSilva, M. A. A. da
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:17:30Z
dc.date.available2018-11-26T16:17:30Z
dc.date.issued2015-12-21
dc.description.abstractIn this work, we used five cell lineages, cultivated in vitro, to show they follow a common functional form to the growth rate: a sigmoidal curve, suggesting that competition and cooperation (usual mechanisms for systems with this behavior) might be present. Both theoretical and experimental investigations, on the causes of this behavior, are challenging for the research field; since the sigmoidal form to the growth rate seems to absorb important properties of such systems, e.g., cell deformation and statistical interactions. We shed some light on this subject by showing how cell spreading affects the radius behavior of the growing colonies. Doing numerical time derivatives of the experimental data, we obtained the growth rates. Using reduced variables for the time and rates, we obtained the collapse of all colonies growth rates onto one curve with sigmoidal shape. This suggests a universal-type behavior, with regime transition related to a morphological transition of adherent cell colonies. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, FFCLRP, Dept Fis, BR-14040901 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, IBILCE, Dept Quim & Ciencias Ambientais, BR-15054000 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, FCFRP, Dept Fis & Quim, BR-14040903 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, IBILCE, Dept Quim & Ciencias Ambientais, BR-15054000 Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/03823-5
dc.format.extent181-188
dc.identifierhttp://dx.doi.org/10.1016/j.jtbi.2015.09.035
dc.identifier.citationJournal Of Theoretical Biology. London: Academic Press Ltd- Elsevier Science Ltd, v. 387, p. 181-188, 2015.
dc.identifier.doi10.1016/j.jtbi.2015.09.035
dc.identifier.fileWOS000365245800019.pdf
dc.identifier.issn0022-5193
dc.identifier.urihttp://hdl.handle.net/11449/160986
dc.identifier.wosWOS:000365245800019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Theoretical Biology
dc.relation.ispartofsjr0,746
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectGrowth rate
dc.subjectCancer
dc.subjectMathematical model
dc.titleThe universal growth rate behavior and regime transition in adherent cell coloniesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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