Manganese oxide increases bleaching efficacy and reduces the cytotoxicity of a 10% hydrogen peroxide bleaching gel

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dc.contributor.authorde Oliveira Ribeiro, Rafael Antonio [UNESP]
dc.contributor.authorZuta, Uxua Ortecho [UNESP]
dc.contributor.authorSoares, Igor Paulino Mendes [UNESP]
dc.contributor.authorAnselmi, Caroline [UNESP]
dc.contributor.authorSoares, Diana Gabriela
dc.contributor.authorBriso, André Luiz Fraga [UNESP]
dc.contributor.authorHebling, Josimeri [UNESP]
dc.contributor.authorde Souza Costa, Carlos Alberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-03-02T11:51:13Z
dc.date.available2023-03-02T11:51:13Z
dc.date.issued2022-01-01
dc.description.abstractObjective: The study aims to assess the effects of a 10% H2O2 bleaching gel with different MnO2 concentrations on the bleaching efficacy (BE), degradation kinetics (DK) of H2O2, and trans-amelodentinal cytotoxicity (TC). Materials and methods: Standardized bovine enamel/dentin disks (n = 96) were placed in artificial pulp chambers, and the bleaching gels were applied for 45 min. Thus, the following groups were established: (G1) no treatment (negative control/NC); (G2) 35% H2O2 (positive control/PC); (G3) 10% H2O2; (G4) 10% H2O2 + 2 mg/mL MnO2; (G5) 10% H2O2 + 6 mg/mL MnO2; and (G6) 10% H2O2 + 10 mg/mL MnO2. After analyzing bleaching efficacy (ΔE00 and ΔWI), the degradation kinetics of H2O2 and trans-amelodentinal cytotoxicity were determined (n = 8, ANOVA/Tukey; p < 0.05). Results: G6 presented BE (ΔE00 and ΔWI) statistically similar to G2, which represented conventional in-office bleaching (p = 0.6795; p > 0.9999). A significant reduction in the diffusion of H2O2 occurred in G3, G4, G5, and G6 compared to G2 (p < 0.0001). The highest DK of H2O2 occurred in G6 (p < 0.0001), which had the lowest TC in comparison with all other bleached groups (p ≤ 0.0186). Conclusion: The addition of 10 mg/mL of MnO2 in a 10% H2O2 bleaching gel potentiates the degradation of this reactive molecule, which increases the BE of the product and decreases TC. Clinical significance: Replacing a 35% H2O2 gel commonly used for conventional in-office dental bleaching by a 10% H2O2 gel containing 10 mg/mL of MnO2 reduces the cytotoxicity of this professional therapy, maintaining its excellent esthetic efficacy.en
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials School of Dentistry São Paulo University (USP)
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1007/s00784-022-04688-3
dc.identifier.citationClinical Oral Investigations.
dc.identifier.doi10.1007/s00784-022-04688-3
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.scopus2-s2.0-85136803679
dc.identifier.urihttp://hdl.handle.net/11449/242208
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.sourceScopus
dc.subjectCell culture
dc.subjectDental materials
dc.subjectTooth bleaching
dc.subjectToxicity
dc.titleManganese oxide increases bleaching efficacy and reduces the cytotoxicity of a 10% hydrogen peroxide bleaching gelen
dc.typeArtigo

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Artigos - Odontologia Restauradora - FOA
Artigos - Clínica Infantil - FOAR