Effects of cyclosporine on adriamycin induced nephropathy

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dc.contributor.authorSoares, Vitor A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:39Z
dc.date.available2014-05-27T11:19:39Z
dc.date.issued1998-12-01
dc.description.abstractThe effect of cyclosporine on adriamycin nephropathy was studied over both short (6 weeks) and long (26 weeks) periods. In the short-term study, cyclosporine was introduced 2 weeks after nephritis induction and in the long-term study, 14 weeks after the first adriamycin injection. The animals with adriamycin nephropathy treated with cyclosporine, studied for 6 weeks, developed proteinuria with increased renal size and glomerular area. The nephrotic animals treated with cyclosporine showed less proteinuria than the nephrotic control animals. There were no differences in glomerular area, creatinine clearance or serum creatinine and kidney weight between the treated nephrotic group and the health control group. The nephrotic animals, studied for the longer period, developed intense proteinuria, decreased creatinine clearance, glomerular necrosis and sclerosis, severe tubulointerstitial nephritis, increased hydroxyproline concentration and tubulointerstitial area. No difference was observed between the nephrotic animals treated with cyclosporine and those not treated. In conclusion, Cyclosporine A reduced proteinuria, glomerular hypertrophy and kidney weight in rats with short-term nephropathy but had no effect on the established nephropathy.en
dc.description.affiliationDepartment of Internal Medicine Division of Nephrology Botucatu Medical School, SP
dc.description.affiliationDepartment of Internal Medicine Division of Nephrology Botucatu Medical School, PO Box 584, SP 18618-970
dc.description.affiliationUnespDepartment of Internal Medicine Division of Nephrology Botucatu Medical School, SP
dc.description.affiliationUnespDepartment of Internal Medicine Division of Nephrology Botucatu Medical School, PO Box 584, SP 18618-970
dc.format.extent385-389
dc.identifierhttp://dx.doi.org/10.1111/j.1440-1797.1998.tb00376.x
dc.identifier.citationNephrology, v. 4, n. 5-6, p. 385-389, 1998.
dc.identifier.doi10.1111/j.1440-1797.1998.tb00376.x
dc.identifier.issn1320-5358
dc.identifier.scopus2-s2.0-0032453728
dc.identifier.urihttp://hdl.handle.net/11449/65613
dc.language.isoeng
dc.relation.ispartofNephrology
dc.relation.ispartofjcr2.178
dc.relation.ispartofsjr0,830
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdriamycin-nephropathy
dc.subjectCyclosporine
dc.subjectGlomerulosclerosis
dc.subjectNephrotic syndrome
dc.subjectProteinuria
dc.subjectcyclosporin a
dc.subjectdoxorubicin
dc.subjectanimal experiment
dc.subjectdrug effect
dc.subjectglomerulosclerosis
dc.subjectkidney disease
dc.subjectkidney mass
dc.subjectmale
dc.subjectnephrotic syndrome
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectproteinuria
dc.subjectrat
dc.titleEffects of cyclosporine on adriamycin induced nephropathyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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