New spectrophotometric method for the determination of mirtazapine in pharmaceutical formulations

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dc.contributor.authorRehman, Fozia
dc.contributor.authorGul, Saima
dc.contributor.authorHussain, Sajjad
dc.contributor.authorKhan, Sabir [UNESP]
dc.contributor.institutionInstitute of Information Technology
dc.contributor.institutionUniversity of Swabi for Woman Gulo-Deri
dc.contributor.institutionInstitute of Engineering Sciences and Technology
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:05:49Z
dc.date.available2018-12-11T17:05:49Z
dc.date.issued2016-06-01
dc.description.abstractA simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully applied to the determination of mirtazapine in their pharmaceutical formulations. The method shows a linear range from 0.2-10 μg mL-1 with a molar absorptivity of 1.53 '10 4L mol-1 cm-1. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.096 μg mL-1 and 0.32μg mL-1 respectively. The developed methodology was successfully applied for the determination of mirtazapine in commercial formulation and the percentage recovery was found 99.91 ± 0.15. The developed methodology promises a feasible, low cost and an efficient method for the routine analysis.en
dc.description.affiliationInterdisciplinary Research Centre in Biomedical Materials(IRCBM) COMSATS Institute of Information Technology
dc.description.affiliationDepartment of Chemistry University of Swabi for Woman Gulo-Deri
dc.description.affiliationFaculty of Materials and Chemical Engineering GIK Institute of Engineering Sciences and Technology
dc.description.affiliationUNESP - Universidade Estadual Paulista Institute of Chemistry Department of Analytical Chemistry
dc.description.affiliationUnespUNESP - Universidade Estadual Paulista Institute of Chemistry Department of Analytical Chemistry
dc.format.extent2913-2915
dc.identifierhttp://dx.doi.org/10.4067/S0717-97072016000200013
dc.identifier.citationJournal of the Chilean Chemical Society, v. 61, n. 2, p. 2913-2915, 2016.
dc.identifier.doi10.4067/S0717-97072016000200013
dc.identifier.issn0717-9707
dc.identifier.issn0717-9324
dc.identifier.scopus2-s2.0-84987800313
dc.identifier.urihttp://hdl.handle.net/11449/173479
dc.language.isoeng
dc.relation.ispartofJournal of the Chilean Chemical Society
dc.relation.ispartofsjr0,201
dc.relation.ispartofsjr0,201
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectIon-association
dc.subjectPharmaceutical formulations
dc.subjectSpectrophotometric
dc.titleNew spectrophotometric method for the determination of mirtazapine in pharmaceutical formulationsen
dc.typeArtigo

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