Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies

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dc.contributor.authorSilva, Danilo Grunig Humberto [UNESP]
dc.contributor.authorBelini Junior, Edis [UNESP]
dc.contributor.authorDe Almeida, Eduardo Alves [UNESP]
dc.contributor.authorBonini-Domingos, Claudia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:49Z
dc.date.available2014-05-27T11:30:49Z
dc.date.issued2013-10-02
dc.description.abstractErythrocytes have an environment of continuous pro-oxidant generation due to the presence of hemoglobin (Hb), which represents an additional and quantitatively significant source of superoxide (O2 •-) generation in biological systems. To counteract oxidative stress, erythrocytes have a self-sustaining antioxidant defense system. Thus, red blood cells uniquely function to protect Hb via a selective barrier allowing gaseous and other ligand transport as well as providing antioxidant protection not only to themselves but also to other tissues and organs in the body. Sickle hemoglobin molecules suffer repeated polymerization/depolymerization generating greater amounts of reactive oxygen species, which can lead to a cyclic cascade characterized by blood cell adhesion, hemolysis, vaso-occlusion, and ischemia-reperfusion injury. In other words, sickle cell disease is intimately linked to a pathophysiologic condition of multiple sources of pro-oxidant processes with consequent chronic and systemic oxidative stress. For this reason, newer therapeutic agents that can target oxidative stress may constitute a valuable means for preventing or delaying the development of organ complications. © © 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationHemoglobin and Hematologic Genetic Diseases Laboratory Department of Biology Sao Paulo State University Julio de Mesquita Filho, 15054-000 Sao Jose do Rio Preto, SP
dc.description.affiliationLaboratory of Aquatic Contamination Biomarkers Department of Chemistry and Environmental Sciences Sao Paulo State University Julio de Mesquita Filho, 15054-000 Sao Jose do Rio Preto, SP
dc.description.affiliationUnespHemoglobin and Hematologic Genetic Diseases Laboratory Department of Biology Sao Paulo State University Julio de Mesquita Filho, 15054-000 Sao Jose do Rio Preto, SP
dc.description.affiliationUnespLaboratory of Aquatic Contamination Biomarkers Department of Chemistry and Environmental Sciences Sao Paulo State University Julio de Mesquita Filho, 15054-000 Sao Jose do Rio Preto, SP
dc.format.extent1101-1109
dc.identifierhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.08.181
dc.identifier.citationFree Radical Biology and Medicine, v. 65, p. 1101-1109.
dc.identifier.doi10.1016/j.freeradbiomed.2013.08.181
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.lattes6713400866382255
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.scopus2-s2.0-84884681035
dc.identifier.urihttp://hdl.handle.net/11449/76776
dc.identifier.wosWOS:000328868900104
dc.language.isoeng
dc.relation.ispartofFree Radical Biology and Medicine
dc.relation.ispartofjcr6.020
dc.relation.ispartofsjr2,178
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectErythrocytes
dc.subjectFree radicals
dc.subjectHemoglobin S
dc.subjectRedox process
dc.titleOxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategiesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes6713400866382255
unesp.author.lattes3279428066176719[4]
unesp.author.orcid0000-0002-4604-9104[3]
unesp.author.orcid0000-0001-6478-8173[2]
unesp.author.orcid0000-0002-4603-9467[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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