Biocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cements

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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorDuarte, MAH
dc.contributor.authorMatsumoto, M. A.
dc.contributor.authorMarques, MEA
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Sagrado Coração (USC)
dc.date.accessioned2014-05-20T13:36:55Z
dc.date.available2014-05-20T13:36:55Z
dc.date.issued2005-08-01
dc.description.abstractMineral trioxide aggregate (MTA) and Portland cement are being used in dentistry as root end-filling materials. However, biocompatibility data concerning genotoxicity and cytotoxicity are needed for complete risk assessment of these compounds. In the present study, genotoxic and cytotoxic effects of MTA and Portland cements were evaluated in vitro using the alkaline single cell gel (comet) assay and trypan blue exclusion test, respectively, on mouse lymphoma cells. The results demonstrated that the single cell gel (comet) assay failed to detect DNA damage after a treatment of cells by MTA and Portland cements for concentrations up to 1000 mu g/ml. Similarly, results showed that none of the compounds tested were cytotoxic. Taken together, these results seem to indicate that MTA and Portland cements are not genotoxins and do not induce cellular death.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol, TOXICAN,Ctr Genotoxins & Carcinogens Evaluat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Sagrado Coracao, Dept Dent Clin, Bauru, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol, TOXICAN,Ctr Genotoxins & Carcinogens Evaluat, BR-18618000 Botucatu, SP, Brazil
dc.format.extent605-607
dc.identifierhttp://dx.doi.org/10.1097/01.don.0000153842.06657.e2
dc.identifier.citationJournal of Endodontics. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 8, p. 605-607, 2005.
dc.identifier.doi10.1097/01.don.0000153842.06657.e2
dc.identifier.issn0099-2399
dc.identifier.lattes5051118752980903
dc.identifier.orcid0000-0001-5389-0105
dc.identifier.urihttp://hdl.handle.net/11449/12708
dc.identifier.wosWOS:000230768200009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Endodontics
dc.relation.ispartofjcr2.886
dc.relation.ispartofsjr1,585
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmineral trioxide aggregatept
dc.subjectPortland cementpt
dc.subjectcomet assaypt
dc.subjectgenotoxicitypt
dc.titleBiocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cementsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[5]
unesp.author.orcid0000-0003-3051-737X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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