Tumescent local anesthesia with ropivacaine in different concentrations in bitches undergoing mastectomy: plasma concentration and post-operative analgesia

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dc.contributor.authorAbimussi, Caio J. X. [UNESP]
dc.contributor.authorMenegheti, Thais M. [UNESP]
dc.contributor.authorWagatsuma, Juliana T. [UNESP]
dc.contributor.authorFloriano, Beatriz P. [UNESP]
dc.contributor.authorArruda, Andre M. M.
dc.contributor.authorSantos, Paulo Sergio Patto dos [UNESP]
dc.contributor.authorOliva, Valeria N. L. S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-03-18T15:55:22Z
dc.date.available2015-03-18T15:55:22Z
dc.date.issued2014-09-01
dc.description.abstractObjective To compare two concentrations of ropivacaine administered for tumescent local anesthesia (TLA) in dogs undergoing mastectomy.Study design Prospective randomized clinical study. Animals Seventeen bitches of various breeds, aged 12 +/- 2 years and weighing 10 +/- 6.5 kg requiring total unilateral or bilateral mastectomy.Methods Dogs were premedicated with acepromazine (0.04 mg kg(-1)) and morphine (0.4 mg kg(-1)) intramuscularly. Anesthesia was induced with propofol (2.5 mg kg(-1)) and midazolam (0.2 mg kg(-1)) intravenously, followed by intubation and maintenance with isoflurane and TLA. Dogs were randomly allocated to receive TLA either with 0.1% ropivacaine (group G1) or with 0.05% ropivacaine (group G05). TLA was performed by insertion of a multihole needle under the skin and infusion of ropivacaine and lactated Ringer's solution at a fixed volume of 15 mL kg(-1). Ropivacaine concentrations in arterial blood were measured by high-performance liquid chromatography. Post-operative pain was assessed using two scales (University of Melbourne pain scale and a modified composite measure pain scale) and von Frey filaments, 4 hours after TLA and at 1 hour intervals until sensitivity was regained. A score above 30% of the maximum possible score was considered a positive indicator of pain.Results Peak plasma concentrations of ropivacaine were measured 240 minutes after TLA in G1. Low concentrations were measured in G05 for 60 minutes, with subsequent increase. Analgesic rescue and return of sensitivity occurred at 7 +/- 2.3 and 7 +/- 1.9 hours (mean +/- SD) after TLA for G1 and G05, respectively.Conclusions and clinical relevance Tumescent local anesthesia with ropivacaine provided satisfactory post-operative analgesia that lasted for several hours, with no difference in duration between the concentrations. No serious side effects were attributed to TLA. Results indicated that 0.05% ropivacaine provided adequate analgesia for mastectomy, however, more studies are required to support this conclusion.en
dc.description.affiliationFMB UNESP, Fac Med, Dept Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationFMVA UNESP, Fac Vet Med, Dept Clin Surg & Anim Reprod, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil
dc.description.affiliationUnespFMB UNESP, Fac Med, Dept Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationUnespFMVA UNESP, Fac Vet Med, Dept Clin Surg & Anim Reprod, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/06439-6
dc.format.extent516-525
dc.identifierhttp://dx.doi.org/10.1111/vaa.12178
dc.identifier.citationVeterinary Anaesthesia And Analgesia. Hoboken: Wiley-blackwell, v. 41, n. 5, p. 516-525, 2014.
dc.identifier.doi10.1111/vaa.12178
dc.identifier.issn1467-2987
dc.identifier.lattes5331938962896664
dc.identifier.orcid0000-0002-8535-5569
dc.identifier.urihttp://hdl.handle.net/11449/117176
dc.identifier.wosWOS:000344008600009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia And Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanalgesiaen
dc.subjectdogen
dc.subjectlocal anesthesiaen
dc.subjectropivacaineen
dc.titleTumescent local anesthesia with ropivacaine in different concentrations in bitches undergoing mastectomy: plasma concentration and post-operative analgesiaen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes5331938962896664[6]
unesp.author.orcid0000-0002-8535-5569[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Anestesiologia - FMB
Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA