Hydroxyapatite and a new fibrin sealant derived from snake venom as scaffold to treatment of cranial defects in rats

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dc.contributor.authorCunha, Marcelo Rodrigues da
dc.contributor.authorMenezes, Fernanda Araujo
dc.contributor.authorSantos, Geovane Ribeiro dos
dc.contributor.authorLopes Pinto, Clovis Antonio
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.authorAmaro Martins, Virginia da Conceicao
dc.contributor.authorGuzzi Plepis, Ana Maria de
dc.contributor.authorFerreira Junior, Rui Seabra [UNESP]
dc.contributor.institutionCentro Universitário Padre Anchieta (UniAnchieta)
dc.contributor.institutionFaculdade de Medicina de Jundiai (FMJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-10-21T21:00:26Z
dc.date.available2015-10-21T21:00:26Z
dc.date.issued2015-01-01
dc.description.abstractBiomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair.en
dc.description.affiliationCtr Univ Padre Anchieta UniAnchieta, Lab Anat, BR-13207270 Jundiai, SP, Brazil
dc.description.affiliationFac Med Jundiai FMJ, Dept Morfol &Patol Basica, BR-13202550 Jundiai, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquista Filho U, CEVAP, BR-18610307 Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquista Filho, Departamento de Doenças Tropicais e Diagnóstico Por Imagem, Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP), BR-18610307 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2012/02689-3
dc.description.sponsorshipIdFAPESP: 2009/53846-9
dc.description.sponsorshipIdFAPESP: 2009/06280-0
dc.description.sponsorshipIdFAPESP: 2012/08101-8
dc.description.sponsorshipIdCNPq: 563582/2010-3
dc.description.sponsorshipIdCAPES: 1219/2011
dc.description.sponsorshipIdCAPES: 23038.000823/2011-21
dc.format.extent196-203
dc.identifierhttp://www.scielo.br/scielo.php?pid=S1516-14392015000100196&script=sci_arttext
dc.identifier.citationMaterials Research-ibero-american Journal Of Materials, v. 18, n. 1, p. 196-203, 2015.
dc.identifier.doi10.1590/1516-1439.316014
dc.identifier.fileS1516-14392015000100196.pdf
dc.identifier.issn1516-1439
dc.identifier.scieloS1516-14392015000100196
dc.identifier.urihttp://hdl.handle.net/11449/129396
dc.identifier.wosWOS:000353061100026
dc.language.isoeng
dc.publisherUniv Fed Sao Carlos, Dept Engenharia Materials
dc.relation.ispartofMaterials Research-ibero-american Journal Of Materials
dc.relation.ispartofjcr1.103
dc.relation.ispartofsjr0,398
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBioceramicen
dc.subjectFibrin sealanten
dc.subjectBone regenerationen
dc.titleHydroxyapatite and a new fibrin sealant derived from snake venom as scaffold to treatment of cranial defects in ratsen
dc.typeArtigo
dcterms.rightsHolderUniv Fed Sao Carlos, Dept Engenharia Materials
unesp.author.lattes6840524602748457[5]
unesp.author.orcid0000-0002-9855-5594[5]

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Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos