Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom

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dc.contributor.authorNishijima, Catarine Massucato [UNESP]
dc.contributor.authorRodrigues, Clenilson Martins [UNESP]
dc.contributor.authorSilva, Marcelo Aparecido [UNESP]
dc.contributor.authorLopes-Ferreira, Monica
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Appl Toxinol
dc.date.accessioned2014-05-20T13:49:53Z
dc.date.available2014-05-20T13:49:53Z
dc.date.issued2009-03-01
dc.description.abstractAround 20,000 snakebites are reported annually in Brazil and 90% of them are inflicted by species of the genus Bothrops. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-hemorrhagic effects of Mouriri pusa Gardn. (Melastomataceae), Byrsonima crassa Niedenzu (Malpighiaceae), Davilla elliptica St. Hill. (Dilleniaceae) and Strychnos pseudoquina St. Hil. (Loganiaceae) against Bothrops jararaca venom. The methanolic extracts from M. pusa (leaves), B. crassa (leaves) and D. elliptica (leaves) showed total neutralization capacity against local hemorrhages. The amenthoflavone and quercetin fractions from B. crassa and the flavonoids fractions (quercetin and myricetin) from M. pusa and D. elliptica also showed total neutralization capacity. We conclude that flavonoids derived from myricetin, quercetin and amenthoflavone play an important role in the anti-hemorrhagic potential of these Brazilian vegetables species against B. jararaca venom.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Organ Chem, Araraquara, SP, Brazil
dc.description.affiliationCtr Appl Toxinol, Instituto Butantan, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Organ Chem, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1072-1080
dc.identifierhttp://dx.doi.org/10.3390/molecules14031072
dc.identifier.citationMolecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 3, p. 1072-1080, 2009.
dc.identifier.doi10.3390/molecules14031072
dc.identifier.fileWOS000264565000014.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/17791
dc.identifier.wosWOS:000264565000014
dc.language.isoeng
dc.publisherMolecular Diversity Preservation International-mdpi
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectFlavonoidsen
dc.subjectAntiophidic plantsen
dc.subjectAnti-hemorrhagicen
dc.subjectBothrops jararacaen
dc.titleAnti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venomen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMolecular Diversity Preservation International-mdpi
unesp.author.lattes3814504901386844[6]
unesp.author.orcid0000-0002-8645-3777[6]
unesp.author.orcid0000-0003-3032-2556[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Fisiologia - IBB
Artigos - Química Orgânica - IQ