Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats

Página do item simplificado
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorPaschoalini, Beatriz Rizzo [UNESP]
dc.contributor.authorBueno, Jéssica Nogueira [UNESP]
dc.contributor.authorStein, Julia [UNESP]
dc.contributor.authorMoreira, Suyane da Silva [UNESP]
dc.contributor.authorManoel, Beatriz de Manoel [UNESP]
dc.contributor.authorFernandes, Glaura Scantamburlo Alves
dc.contributor.authorHisano, Hamilton
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2023-03-01T21:03:32Z
dc.date.available2023-03-01T21:03:32Z
dc.date.issued2022-01-01
dc.description.abstractSince studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina–UEL
dc.description.affiliationEmbrapa Environment
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista–Botucatu (UNESP)
dc.identifierhttp://dx.doi.org/10.1080/01480545.2022.2105864
dc.identifier.citationDrug and Chemical Toxicology.
dc.identifier.doi10.1080/01480545.2022.2105864
dc.identifier.issn1525-6014
dc.identifier.issn0148-0545
dc.identifier.scopus2-s2.0-85135248249
dc.identifier.urihttp://hdl.handle.net/11449/241444
dc.language.isoeng
dc.relation.ispartofDrug and Chemical Toxicology
dc.sourceScopus
dc.subjectbenzo(a)pyrene
dc.subjectendocrine disruptor
dc.subjectfemale fertility
dc.subjectjuvenile period
dc.subjectPolycyclic aromatic hydrocarbon
dc.subjectpuberty
dc.subjectrats
dc.titleLong-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-6043-1131[8]
unesp.author.orcid0000-0002-2373-9399[10]

Arquivos

Coleções

Botucatu - CEATOX - Centro de Assistência Toxicológica