Acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents. A systematic review and meta-analysis

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dc.contributor.authorGuerra, Rodrigo [UNESP]
dc.contributor.authorKawano, Paulo Roberto [UNESP]
dc.contributor.authorAmaro, Marcelo Petean
dc.contributor.authorYamamoto, Hamilto Akihissa [UNESP]
dc.contributor.authorGomes Filho, Fernando Ferreira [UNESP]
dc.contributor.authorAmaro, Joao Luiz [UNESP]
dc.contributor.authorEl Dibl, Regina Paolucci [UNESP]
dc.contributor.authorGarcia-Perdomo, Herney Andres
dc.contributor.authorReis, Leonardo Oliveira
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniv Valle
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2022-11-30T15:19:52Z
dc.date.available2022-11-30T15:19:52Z
dc.date.issued2022-01-01
dc.description.abstractObjectives: Thrombosis is a major cause of early allograft loss in renal transplantation. Herein, we assessed the frequency of acute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents. Methods: We performed a systematic review of all available case series studies of anticoagulant and/or antiplatelet prophylaxis of thrombosis in renal transplantation. The data were pooled in a proportional meta-analysis. Results: Twenty-one case series were identified from 7,160 retrieved titles. A total of 3,246 patients were analyzed (1,718 treated with antiplatelet and/or anticoagulant agents and 1,528 non-treated control subjects). Allograft thrombosis occurred in 7.24% (95% CI 3.45 to 12.27%) of the patients receiving no intervention compared with 3.38% (95% CI 1.45 to 6.1%), 1.2% (95% CI 0.6 to 2.1%) and 0.47% (95% CI 0.001 to 1.79%) of the patients in the anticoagulant, aspirin, and aspirin + anticoagulant groups, respectively. The bleeding complication rate for anticoagulants was significantly higher than in the other groups. Conclusions: Our data suggests that anticoagulants, and aspirin, either alone or in association with an anticoagulant, seem to have a low frequency of acute allograft thrombosis after kidney transplantation. Higher hemorrhagic complication rates might occur when anticoagulants are used.en
dc.description.affiliationUNESP, Med Sch Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUniv Valle, Sch Med, Cali, Colombia
dc.description.affiliationUniv Estadual Campinas, UroSci, UNICAMP, Campinas, SP, Brazil
dc.description.affiliationPontifical Catholic Univ Campinas, PUC Campinas, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Med Sch Botucatu, Botucatu, SP, Brazil
dc.format.extent129-141
dc.identifier.citationAmerican Journal Of Clinical And Experimental Urology. Madison: E-century Publishing Corp, v. 10, n. 3, p. 129-141, 2022.
dc.identifier.issn2330-1910
dc.identifier.urihttp://hdl.handle.net/11449/237927
dc.identifier.wosWOS:000813449100001
dc.language.isoeng
dc.publisherE-century Publishing Corp
dc.relation.ispartofAmerican Journal Of Clinical And Experimental Urology
dc.sourceWeb of Science
dc.subjectAnticoagulants
dc.subjectAspirin
dc.subjectKidney transplantation
dc.subjectMeta-analysis
dc.subjectThrombosis
dc.titleAcute graft thrombosis in patients who underwent renal transplant and received anticoagulant or antiplatelet agents. A systematic review and meta-analysisen
dc.typeResenha
dcterms.rightsHolderE-century Publishing Corp

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