Estrogen receptors alpha and beta in male and female gerbil prostates

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dc.contributor.authorRochel-Maia, Sabrina S.
dc.contributor.authorSantos, Fernanda C.A. [UNESP]
dc.contributor.authorAlonso-Magdalena, Paloma
dc.contributor.authorGóes, Rejane Maira [UNESP]
dc.contributor.authorVilamaior, Patricia S.L. [UNESP]
dc.contributor.authorWarner, Margaret
dc.contributor.authorGustafsson, Jan-Åke
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Houston
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionKarolinska Institute
dc.date.accessioned2014-05-27T11:27:29Z
dc.date.available2014-05-27T11:27:29Z
dc.date.issued2013-01-01
dc.description.abstractThe Mongolian gerbil (Meriones unguiculatus, Gerbilinae: Muridae) is useful for prostate studies, because both males and females spontaneously develop prostatic disorders with age. Estrogens regulate prostate homeostasis via two estrogen receptors, ER alpha (ESR1) and ER beta (ESR2), but the cellular distribution and regulation of these receptors in the gerbil prostate has not been described. Both receptors were localized by immunohistochemistry in the ventral prostate of intact male and female gerbils, in males 7 and 21 days after castration, and in females treated with testosterone for 7 and 21 days. In male and female adult gerbils, ER alpha was detected mainly in prostatic stromal cells, whereas ER beta was present mostly in secretory and basal cells. More ER alpha-positive stromal cells were found in females than in males, as was a reduction toward the male value in females treated with testosterone. Castration did not alter ER alpha expression. Testosterone was necessary for maintenance of ER beta in the male prostate epithelium: ER beta expression declined markedly in prostates of males older than 1 yr, and castration of 4-mo-old males caused a reduction in ER beta to levels seen in 1-yr-old males. Because ER beta is an antiproliferative receptor, its loss with age may predispose the aging gerbil to proliferative diseases of the prostate. © 2013 by the Society for the Study of Reproduction, Inc.en
dc.description.affiliationDepartment of Cell Biology University of Campinas, Campinas, São Paulo
dc.description.affiliationDepartment of Biology and Biochemistry University of Houston, Houston, TX
dc.description.affiliationDepartment of Morphology Federal University of Goiás, Goiânia, Goiás
dc.description.affiliationDepartment of Biology São Paulo State University São José do Rio Preto, São Paulo
dc.description.affiliationDepartment of Biosciences and Nutrition Karolinska Institute, Stockholm
dc.description.affiliationUnespDepartment of Biology São Paulo State University São José do Rio Preto, São Paulo
dc.identifierhttp://dx.doi.org/10.1095/biolreprod.112.103614
dc.identifier.citationBiology of Reproduction, v. 88, n. 1, 2013.
dc.identifier.doi10.1095/biolreprod.112.103614
dc.identifier.issn0006-3363
dc.identifier.issn1529-7268
dc.identifier.lattes0947193347312157
dc.identifier.lattes1445259468526188
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.scopus2-s2.0-84877073435
dc.identifier.urihttp://hdl.handle.net/11449/74212
dc.identifier.wosWOS:000314357700006
dc.language.isoeng
dc.relation.ispartofBiology of Reproduction
dc.relation.ispartofjcr3.184
dc.relation.ispartofsjr1,446
dc.relation.ispartofsjr1,446
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCastration
dc.subjectEstradiol/estradiol receptor
dc.subjectEstrogen receptor
dc.subjectFemale
dc.subjectGerbil
dc.subjectProstate
dc.subjectSteroid hormones/steroid hormone receptors
dc.subjectStroma
dc.subjectTestosterone
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjecttestosterone
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbasal cell
dc.subjectcastration
dc.subjectcellular distribution
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgerbil
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprostate ventral lobe
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectsecretory cell
dc.subjectstroma cell
dc.subjectAnimals
dc.subjectEstrogen Receptor alpha
dc.subjectEstrogen Receptor beta
dc.subjectEstrous Cycle
dc.subjectGene Expression Regulation
dc.subjectGerbillinae
dc.subjectMale
dc.subjectRandom Allocation
dc.titleEstrogen receptors alpha and beta in male and female gerbil prostatesen
dc.typeArtigo
dcterms.licensehttp://www.biolreprod.org/site/misc/BORauthorship.pdf
unesp.author.lattes0947193347312157
unesp.author.lattes1445259468526188
unesp.author.lattes7066358123790434[5]
unesp.author.orcid0000-0001-9559-5497[5]
unesp.author.orcid0000-0002-0970-4288[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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