Quantification of rifaximin in tablets by an environmentally friendly visible spectrophotometric method

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dc.contributor.authorBrbaklic, Vesna
dc.contributor.authorKogawa, Ana Carolina [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversity of Novi Sad
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:45Z
dc.date.available2018-12-11T17:34:45Z
dc.date.issued2017-11-01
dc.description.abstractIntroduction: Rifaximin is an antibiotic with a wide spectrum of antibacterial activity. Due to its non-absorbable nature and mechanism of action, it is commonly used for treating travelers’ diarrhea. It still does not have standardized methods in most official compendiums. This paper aimed to validate an environmentally friendly spectrophotometric method in the visible region for quantification of rifaximin in tablets. Method: Validation was performed in terms of International Conference on Harmonization guidelines, examining linearity, precision, selectivity, specificity, accuracy and robustness. The method considered rifaximin solutions in purified water and ethyl alcohol (5:1, v/v) at a wavelength of 477 nm. Conclusion: The method showed great linearity in the concentration range between 15 and 50 µg L-1 with correlation coefficient higher than 0.9998. Selectivity was determined by submitting the rifaximin in tablets to the forced degradation in ultraviolet light and acidic, basic, oxidative, neutral solution. The interday and intraday precision presented deviations of less than 1 %. The accuracy was 99.12 %. The method was robust to the variation in wavelength and source of purified water. The validated method proved to be fast, cost effective and suitable for routine quality control of rifaximin in tablets, avoiding the use of polluting reagents.en
dc.description.affiliationDepartment of Pharmacy Faculty of Medicine University of Novi Sad
dc.description.affiliationDepartment of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista-UNESP
dc.description.affiliationUnespDepartment of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista-UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent532-537
dc.identifierhttp://dx.doi.org/10.2174/1573412912666160906144024
dc.identifier.citationCurrent Pharmaceutical Analysis, v. 13, n. 6, p. 532-537, 2017.
dc.identifier.doi10.2174/1573412912666160906144024
dc.identifier.issn1875-676X
dc.identifier.issn1573-4129
dc.identifier.scopus2-s2.0-85032902691
dc.identifier.urihttp://hdl.handle.net/11449/179333
dc.language.isoeng
dc.relation.ispartofCurrent Pharmaceutical Analysis
dc.relation.ispartofsjr0,224
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectEnvironmentally friendly
dc.subjectMethod validation
dc.subjectRifaximin
dc.subjectSpectrophotometry in the visible region
dc.subjectTablets
dc.titleQuantification of rifaximin in tablets by an environmentally friendly visible spectrophotometric methoden
dc.typeArtigo

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Artigos - Fármacos e Medicamentos - FCFAR