S-100 protein: is it useful as a tumour marker in diagnostic immunocytochemistry

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dc.contributor.authorSchmitt, F. C.
dc.contributor.authorBacchi, C. E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T05:30:33Z
dc.date.available2014-05-27T05:30:33Z
dc.date.issued1989-01-01
dc.description.abstractA heterogeneous group of 159 tumours was studied for the presence of S-100 protein by the immunoperoxidase technique in order to determine whether this marker may be of value in facilitating immunocytochemical diagnosis. Among cases of melanocytic and pigmented lesions, S-100 was widely distributed and demonstrated the strongest degrees of reactivity. S-100 protein was identified in virtually all nerve sheath tumours such as schwannomas, neurofibromas, myxoid sheath nerve tumour and also in some tumours of controversial histogenesis such as granular cell tumours. The great majority of carcinomas did not express S-100, with only two cases of breast carcinoma displaying focal S-100 staining. In a miscellaneous group of tumours S-100 was demonstrated in chordomas, myoepitheliomas and Wilms' tumour with Schwann cell differentiation. Despite its presence in a wide array of cell types, S-100 protein continues to be an extremely useful marker especially for soft tissue and peripheral nervous system tumours.en
dc.description.affiliationUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, BOTUCATU MED SCH, FAC MED,DEPT PATOL, BR-18610 BOTUCATU, SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, BOTUCATU MED SCH, FAC MED, DEPT PATOL, BR-18610 BOTUCATU,SP,BRAZIL
dc.format.extent281-288
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2559.1989.tb03078.x
dc.identifier.citationHistopathology, v. 15, n. 3, p. 281-288, 1989.
dc.identifier.doi10.1111/j.1365-2559.1989.tb03078.x
dc.identifier.issn0309-0167
dc.identifier.scopus2-s2.0-0024470533
dc.identifier.urihttp://hdl.handle.net/11449/130648
dc.identifier.wosWOS:A1989AQ80500007
dc.language.isoeng
dc.publisherBlackwell Science
dc.relation.ispartofHistopathology
dc.relation.ispartofjcr3.267
dc.relation.ispartofsjr1,341
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectProtein s 100
dc.subjectTumor marker
dc.subjectBreast carcinoma
dc.subjectChordoma
dc.subjectGranular cell tumor
dc.subjectHstochemistry
dc.subjectHuman
dc.subjectHuman cell
dc.subjectMajor clinical study
dc.subjectMelanoma
dc.subjectMyoepithelioma
dc.subjectNephroblastoma
dc.subjectNeurilemoma
dc.subjectNeurofibroma
dc.subjectPriority journal
dc.subjectHuman
dc.subjectImmunohistochemistry
dc.subjectNervous System Neoplasms
dc.subjectS100 Proteins
dc.subjectTumor Markers, Biological
dc.titleS-100 protein: is it useful as a tumour marker in diagnostic immunocytochemistryen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Science Ltd
unesp.author.orcid0000-0003-1006-6946[1]
unesp.author.orcid0000-0002-3711-8681[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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