Influence of Manganese Oxide on the Esthetic Efficacy and Toxicity Caused by Conventional In-office Tooth Bleaching Therapy

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dc.contributor.authorRibeiro, Rao [UNESP]
dc.contributor.authorde Oliveira Duque, C. C. [UNESP]
dc.contributor.authorOrtecho-Zuta, U. [UNESP]
dc.contributor.authorLeite, M. L. [UNESP]
dc.contributor.authorHebling, J. [UNESP]
dc.contributor.authorSoares, D. G.
dc.contributor.authorde Souza Costa, C. A.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-03-01T21:11:36Z
dc.date.available2023-03-01T21:11:36Z
dc.date.issued2022-07-01
dc.description.abstractOBJECTIVE: This study aimed to evaluate the esthetic efficacy, cytotoxicity, and kinetics of decomposition of hydrogen peroxide (H2O2) present in a commercial bleaching gel with 35% H2O2 (BG35%) chemically activated with manganese oxide (MnO2). METHODS AND MATERIALS: After incorporating 2 mg/mL, 6 mg/mL, and 10 mg/mL of MnO2 into BG35%, the stability of pH and temperature of the products were analyzed. To assess the esthetic efficacy (ΔE and ΔWI), the BG35%s with MnO2 were applied for 45 minutes on enamel/dentin discs (DiE/D). BG35% or no treatment were used as positive (PC) and negative (NC) controls, respectively. To analyze the cell viability (CV) and oxidative stress (OXS), the same bleaching protocols were performed on DiE/D adapted to artificial pulp chambers. The extracts (culture medium + gel components that diffused through the discs) were applied to pulp cells and submitted to H2O2 quantification. BG35% with MnO2 that showed the best results was evaluated relative to kinetic decomposition of H2O2, with consequent generation of free radicals (FR) and hydroxyl radicals (OH•). The data were submitted to the one-way analysis of variance complemented by Tukey post-test (α=0.05). Data on kinetics of H2O2 decomposition were submitted to the Student's-t test (α=0.05). RESULTS: All the BG35%s with MnO2 showed stability of pH and temperature, and the gel with 10 mg/mL of this activator had an esthetic efficacy 31% higher than that of the PC (p<0.05). Reduction in OXS and trans-amelodentinal diffusion of H2O2 occurred when all the BG35%s with MnO2 were used. The addition of 6 and 10 mg/mL of MnO2 to BG35% increased the CV in comparison with PC, confirmed by the cell morphology analysis. An increase in FR and OH• formation was observed when 10 mg/mL of MnO2 was added to BG35%. CONCLUSION: Catalysis of BG35% with MnO2 minimized the trans-amelodentinal diffusion of H2O2 and toxicity of the product to pulp cells. BG35% containing 10 mg/mL of MnO2 potentiated the decomposition of H2O2, enhancing the generation of FR and OH•, as well as the efficacy of the in-office tooth therapy.en
dc.description.affiliationRafael Antonio de Oliveira Ribeiro Department of Dental Materials and Prosthodontics Univ Estadual Paulista - UNESP Araraquara School of Dentistry
dc.description.affiliationCarla Caroline de Oliveira Duque Department of Dental Materials and Prosthodontics Univ Estadual Paulista -UNESP Araraquara School of Dentistry
dc.description.affiliationDepartment of Dental Materials and Prosthodontics Univ Estadual Paulista -UNESP Araraquara School of Dentistry
dc.description.affiliationDepartment of Orthodontics and Pediatric Dentistry Univ Estadual Paulista - UNESP Araraquara School of Dentistry
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials Univ de São Paulo - USP Bauru School of Dentistry
dc.description.affiliationast;Carlos Alberto de Souza Costa, professor, Department of Physiology and Pathology, Univ Estadual Paulista - UNESP, Araraquara School of Dentistry, Araraquara, SP, Brazil
dc.description.affiliationUnespRafael Antonio de Oliveira Ribeiro Department of Dental Materials and Prosthodontics Univ Estadual Paulista - UNESP Araraquara School of Dentistry
dc.description.affiliationUnespCarla Caroline de Oliveira Duque Department of Dental Materials and Prosthodontics Univ Estadual Paulista -UNESP Araraquara School of Dentistry
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics Univ Estadual Paulista -UNESP Araraquara School of Dentistry
dc.description.affiliationUnespDepartment of Orthodontics and Pediatric Dentistry Univ Estadual Paulista - UNESP Araraquara School of Dentistry
dc.format.extent425-436
dc.identifierhttp://dx.doi.org/10.2341/20-257-L
dc.identifier.citationOperative dentistry, v. 47, n. 4, p. 425-436, 2022.
dc.identifier.doi10.2341/20-257-L
dc.identifier.issn1559-2863
dc.identifier.scopus2-s2.0-85137126604
dc.identifier.urihttp://hdl.handle.net/11449/241588
dc.language.isoeng
dc.relation.ispartofOperative dentistry
dc.sourceScopus
dc.titleInfluence of Manganese Oxide on the Esthetic Efficacy and Toxicity Caused by Conventional In-office Tooth Bleaching Therapyen
dc.typeArtigo
unesp.author.orcid0000-0001-8100-3294[1]
unesp.author.orcid0000-0002-5898-4132[2]
unesp.author.orcid0000-0002-2922-3609[3]
unesp.author.orcid0000-0001-6650-3637[4]
unesp.author.orcid0000-0002-2846-2325[5]
unesp.author.orcid0000-0002-1485-6104[6]
unesp.author.orcid0000-0002-7455-6867[7]

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