The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats

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dc.contributor.authorEngel, Letícia Estevam
dc.contributor.authorde Souza, Francilene Lima Agostinho
dc.contributor.authorGiometti, Ines Cristina
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorMariano, Thaoan Bruno
dc.contributor.authorFerreira, Natalia Zamberlan
dc.contributor.authorPinheiro, Dyovana Gomes
dc.contributor.authorFloriano, Rafael Stuani
dc.contributor.authorAguiar, Andreo Fernando
dc.contributor.authorCicogna, Antônio Carlos [UNESP]
dc.contributor.authorVechetti, Ivan José
dc.contributor.authorPacagnelli, Francis Lopes
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Northern Paraná (UNOPAR)
dc.contributor.institutionUniversity of Nebraska-Lincoln
dc.date.accessioned2023-07-29T14:03:57Z
dc.date.available2023-07-29T14:03:57Z
dc.date.issued2022-11-01
dc.description.abstractAim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats. Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. Key findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT. Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein.en
dc.description.affiliationUniversity of Western São Paulo (UNOESTE), SP
dc.description.affiliationSão Paulo State University (UNESP), SP
dc.description.affiliationUniversity of Northern Paraná (UNOPAR), PR
dc.description.affiliationUniversity of Nebraska-Lincoln Department of Nutrition and Health Sciences
dc.description.affiliationUnespSão Paulo State University (UNESP), SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 139942/2017-3
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.120959
dc.identifier.citationLife Sciences, v. 308.
dc.identifier.doi10.1016/j.lfs.2022.120959
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.scopus2-s2.0-85138105542
dc.identifier.urihttp://hdl.handle.net/11449/249155
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.sourceScopus
dc.subjectHypertension
dc.subjectMAP kinase signaling system
dc.subjectPapillary muscles
dc.subjectPhysical exercise
dc.titleThe high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive ratsen
dc.typeArtigo

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