Central mechanisms involved in pilocarpine-induced pressor response

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dc.contributor.authorTakakura, Ana C. [UNESP]
dc.contributor.authorMoreira, Thiago S.
dc.contributor.authorBorella, Thais L. [UNESP]
dc.contributor.authorPaulin, Renata F. [UNESP]
dc.contributor.authorColombari, Debora S. A. [UNESP]
dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:46:15Z
dc.date.available2014-05-20T13:46:15Z
dc.date.issued2011-10-28
dc.description.abstractPilocarpine (cholinergic muscarinic agonist) injected peripherally may act centrally to produce pressor responses; in the present study, using c-fos immunoreactive expression, we investigated the forebrain and brainstem areas activated by pressor doses of intravenous (i.v.) pilocarpine. In addition, the importance of vasopressin secretion and/or sympathetic activation and the effects of lesions in the anteroventral third ventricle (AV3V) region in awake rats were also investigated. In male Holtzman rats, pilocarpine (0.04 to 4 mu mol/kg b.w.) i.v. induced transitory hypotension followed by long lasting hypertension. Sympathetic blockade with prazosin (1 mg/kg b.w.) i.v. or AV3V lesions (1 day) almost abolished the pressor response to i. v. pilocarpine (2 mu mol/kg b.w.), whereas the vasopressin antagonist (10 mu g/kg b.w.) i.v. reduced the response to pilocarpine. Pilocarpine (2 and 4 mu mol/kg b.w.) i.v. increased the number of c-fos immunoreactive cells in the subfornical organ, paraventricular and supraoptic nuclei of the hypothalamus, organ vasculosum of the lamina terminalis, median preoptic nucleus, nucleus of the solitary tract and caudal and rostral ventrolateral medulla. These data suggest that i.v. pilocarpine activates specific forebrain and brainstem mechanisms increasing sympathetic activity and vasopressin secretion to induce pressor response. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 10/09776-3
dc.description.sponsorshipIdFAPESP: 06/60174-9
dc.description.sponsorshipIdFAPESP: 07/06430-6
dc.description.sponsorshipIdCNPq: 300472/2005-6
dc.description.sponsorshipIdCNPq: 501971/2007-6
dc.format.extent34-42
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2011.05.008
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 164, n. 1-2, p. 34-42, 2011.
dc.identifier.doi10.1016/j.autneu.2011.05.008
dc.identifier.fileWOS000295346500006.pdf
dc.identifier.issn1566-0702
dc.identifier.lattes4544450092427426
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16343
dc.identifier.wosWOS:000295346500006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofjcr2.605
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCholinergic mechanismsen
dc.subjectArterial pressureen
dc.subjectHypertensionen
dc.subjectSympathetic activityen
dc.subjectVasopressinen
dc.titleCentral mechanisms involved in pilocarpine-induced pressor responseen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4544450092427426[7]
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0002-1395-4036[7]
unesp.author.orcid0000-0003-1167-4441[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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