Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats
dc.contributor.author | Gomes-Ferreira, Pedro Henrique Silva [UNESP] | |
dc.contributor.author | Frigério, Paula Buzo [UNESP] | |
dc.contributor.author | de Moura, Juliana [UNESP] | |
dc.contributor.author | Duarte, Nathália Dantas [UNESP] | |
dc.contributor.author | de Oliveira, Danila [UNESP] | |
dc.contributor.author | Deering, Joseph | |
dc.contributor.author | Grandfield, Kathryn | |
dc.contributor.author | Okamoto, Roberta [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | McMaster University | |
dc.date.accessioned | 2023-07-29T13:43:36Z | |
dc.date.available | 2023-07-29T13:43:36Z | |
dc.date.issued | 2023-02-01 | |
dc.description.abstract | (1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality. | en |
dc.description.affiliation | Department of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP | |
dc.description.affiliation | Department of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP | |
dc.description.affiliation | Department of Materials Science and Engineering McMaster University | |
dc.description.affiliation | School of Biomedical Engineering McMaster University | |
dc.description.affiliationUnesp | Department of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP | |
dc.description.affiliationUnesp | Department of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP | |
dc.identifier | http://dx.doi.org/10.3390/biology12020228 | |
dc.identifier.citation | Biology, v. 12, n. 2, 2023. | |
dc.identifier.doi | 10.3390/biology12020228 | |
dc.identifier.issn | 2079-7737 | |
dc.identifier.scopus | 2-s2.0-85148936891 | |
dc.identifier.uri | http://hdl.handle.net/11449/248422 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biology | |
dc.source | Scopus | |
dc.subject | dental implants | |
dc.subject | men | |
dc.subject | osteoporosis | |
dc.subject | teriparatide | |
dc.subject | vitamin D | |
dc.title | Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats | en |
dc.type | Artigo | |
unesp.author.orcid | 0000-0002-8936-3662[1] | |
unesp.author.orcid | 0000-0002-5012-5093[2] | |
unesp.author.orcid | 0000-0002-5207-6360[4] | |
unesp.author.orcid | 0000-0003-2868-0944[6] | |
unesp.author.orcid | 0000-0002-0188-9580[7] | |
unesp.author.orcid | 0000-0002-6773-6966[8] |