Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats

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dc.contributor.authorGomes-Ferreira, Pedro Henrique Silva [UNESP]
dc.contributor.authorFrigério, Paula Buzo [UNESP]
dc.contributor.authorde Moura, Juliana [UNESP]
dc.contributor.authorDuarte, Nathália Dantas [UNESP]
dc.contributor.authorde Oliveira, Danila [UNESP]
dc.contributor.authorDeering, Joseph
dc.contributor.authorGrandfield, Kathryn
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionMcMaster University
dc.date.accessioned2023-07-29T13:43:36Z
dc.date.available2023-07-29T13:43:36Z
dc.date.issued2023-02-01
dc.description.abstract(1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality.en
dc.description.affiliationDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationDepartment of Materials Science and Engineering McMaster University
dc.description.affiliationSchool of Biomedical Engineering McMaster University
dc.description.affiliationUnespDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP
dc.identifierhttp://dx.doi.org/10.3390/biology12020228
dc.identifier.citationBiology, v. 12, n. 2, 2023.
dc.identifier.doi10.3390/biology12020228
dc.identifier.issn2079-7737
dc.identifier.scopus2-s2.0-85148936891
dc.identifier.urihttp://hdl.handle.net/11449/248422
dc.language.isoeng
dc.relation.ispartofBiology
dc.sourceScopus
dc.subjectdental implants
dc.subjectmen
dc.subjectosteoporosis
dc.subjectteriparatide
dc.subjectvitamin D
dc.titleEvaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-8936-3662[1]
unesp.author.orcid0000-0002-5012-5093[2]
unesp.author.orcid0000-0002-5207-6360[4]
unesp.author.orcid0000-0003-2868-0944[6]
unesp.author.orcid0000-0002-0188-9580[7]
unesp.author.orcid0000-0002-6773-6966[8]

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