The effect of analogues of angiotensin II on drinking and cardiovascular responses to central angiotensin II in the rat.

Página do item simplificado
dc.contributor.authorCamargo, L. A. [UNESP]
dc.contributor.authorDe Luca, L. A. [UNESP]
dc.contributor.authorMenani, J. V. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorSaad, W. A. [UNESP]
dc.contributor.authorSilveira, J. E. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:53:49Z
dc.date.available2022-04-28T19:53:49Z
dc.date.issued1991-11-01
dc.description.abstract1. Intracerebroventricular (I.C.V.) infusion (60 ng h‐1) of Isoleu5‐angiotensin II (Isoleu5‐‐AngII) and des‐amine‐angiotensin II (des‐amine‐AngII) in rats caused increased drinking behaviour and an increase in arterial blood pressure. 2. Des‐amine‐AngII caused similar increases in heart rate and arterial blood pressure as AngII. 3. Previous I.C.V. injection of the antagonists [Leu8]‐AngII, des‐amine‐[Leu8]‐AngII and octanoyl‐[Leu8]‐AngII prevented the increases in heart rate and blood pressure produced by I.C.V. infusion of AngII and caused partial reduction of the dipsogenic response. 4. The three antagonists had no effect on the increase in arterial blood pressure and heart rate caused by des‐amine‐AngII. The drinking response was reduced by previous injection of [Leu8]‐AngII and des‐amine‐[Leu8]‐AngII but not by octanoyl‐[Leu8]‐AngII. 5. In conclusion, Isoleu5‐AngII and des‐amine‐AngII increase drinking behaviour, arterial blood pressure and heart rate when infused into the cerebral ventricle of rats. The study with the antagonists showed that des‐amine‐AngII probably binds more strongly to AngII‐receptors. © 1991 The Physiological Societyen
dc.description.affiliationDepartment of Physiology School of Dentistry UNESP, Araraquara, Sao Paulo, 14800
dc.description.affiliationUnespDepartment of Physiology School of Dentistry UNESP, Araraquara, Sao Paulo, 14800
dc.format.extent513-518
dc.identifierhttp://dx.doi.org/10.1113/jphysiol.1991.sp018848
dc.identifier.citationThe Journal of Physiology, v. 443, n. 1, p. 513-518, 1991.
dc.identifier.doi10.1113/jphysiol.1991.sp018848
dc.identifier.issn1469-7793
dc.identifier.issn0022-3751
dc.identifier.scopus2-s2.0-0025955661
dc.identifier.urihttp://hdl.handle.net/11449/223922
dc.language.isoeng
dc.relation.ispartofThe Journal of Physiology
dc.sourceScopus
dc.titleThe effect of analogues of angiotensin II on drinking and cardiovascular responses to central angiotensin II in the rat.en
dc.typeArtigo

Arquivos

Coleções

Artigos - Fisiologia e Patologia - FOAR